A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience
Objective: The aim of this study was to evaluate thyroid functions in Cushing’s syndrome (CS), the dynamic changes of thyroid hormones and antithyroid antibodies in Cushing’s disease (CD) pre- and postoperatively. Design and methods: This is a retrospective study enrolling 118 patients with CS (10...
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Bioscientifica
2019-08-01
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doaj-43e3e5e7e5ec4a86a1d5bd9adaa58bad2020-11-25T00:44:20ZengBioscientificaEndocrine Connections2049-36142049-36142019-08-018811761185https://doi.org/10.1530/EC-19-0309A study of thyroid functions in patients with Cushing’s syndrome: a single-center experienceBoni Xiang0Ran Tao1Xinhua Liu2Xiaoming Zhu3Min He4Zengyi Ma5Yehong Yang6Zhaoyun Zhang7Yiming Li8Zhenwei Yao9Yongfei Wang10Hongying Ye11Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, ChinaObjective: The aim of this study was to evaluate thyroid functions in Cushing’s syndrome (CS), the dynamic changes of thyroid hormones and antithyroid antibodies in Cushing’s disease (CD) pre- and postoperatively. Design and methods: This is a retrospective study enrolling 118 patients with CS (102 CD, 10 adrenal CS and 6 ectopic adrenocorticotropic syndrome (EAS)). Thyroid functions (thyroid-stimulation hormone (TSH), T3, free T3 (FT3), T4 and free T4 (FT4)) were measured in all CS at the time of diagnosis and in all CD 3 mon ths after transsphenoidal pituitary tumor resection. Postoperative hormone monitoring within 3 months was conducted in 9 CD patients completing remission. Twenty-eight remitted CD patients experienced hormone and antithyroid antibody evaluation preoperatively and on the 3rd, 6th and 12th month after surgery. Results: TSH, T3 and FT3 were below the reference range in 31%, 69% and 44% of the 118 CS patients. Remitted CD patients (81/102) had significantly higher TSH (P = 0.000), T3 (P = 0.000) and FT3 (P = 0.000) than those in the non-remission group (21/102). After remission of CD, TSH, T3 and FT3 showed a significant increase, with a few cases above the reference range. By 12 months, most CD patients’ thyroid fu nctions returned to normal. Thyroid hormones (including TSH, T3 and FT3) were negatively associated with serum cortisol levels both before and after surgery. No signific ant changes of antithyroid autoantibodies were observed. Conclusions: TSH, T3 and FT3 are suppressed in endogenous hypercortisolemia. After remission of CD, TSH, T3 and FT3 increased significantly, even a bove the reference range, but returned to normal 1 year after surgery in most cases. Anti thyroid antibodies did not change significantly after remission of CD. https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0309.xmlCushing’s syndromeCushing’s diseasecortisolthyroid hormonesantithyroid antibodies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boni Xiang Ran Tao Xinhua Liu Xiaoming Zhu Min He Zengyi Ma Yehong Yang Zhaoyun Zhang Yiming Li Zhenwei Yao Yongfei Wang Hongying Ye |
spellingShingle |
Boni Xiang Ran Tao Xinhua Liu Xiaoming Zhu Min He Zengyi Ma Yehong Yang Zhaoyun Zhang Yiming Li Zhenwei Yao Yongfei Wang Hongying Ye A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience Endocrine Connections Cushing’s syndrome Cushing’s disease cortisol thyroid hormones antithyroid antibodies |
author_facet |
Boni Xiang Ran Tao Xinhua Liu Xiaoming Zhu Min He Zengyi Ma Yehong Yang Zhaoyun Zhang Yiming Li Zhenwei Yao Yongfei Wang Hongying Ye |
author_sort |
Boni Xiang |
title |
A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience |
title_short |
A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience |
title_full |
A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience |
title_fullStr |
A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience |
title_full_unstemmed |
A study of thyroid functions in patients with Cushing’s syndrome: a single-center experience |
title_sort |
study of thyroid functions in patients with cushing’s syndrome: a single-center experience |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2019-08-01 |
description |
Objective: The aim of this study was to evaluate thyroid functions in Cushing’s syndrome (CS), the dynamic changes of thyroid hormones and antithyroid antibodies in Cushing’s disease (CD) pre- and postoperatively.
Design and methods: This is a retrospective study enrolling 118 patients with CS (102 CD, 10 adrenal CS and 6 ectopic adrenocorticotropic syndrome (EAS)). Thyroid functions (thyroid-stimulation hormone (TSH), T3, free T3 (FT3), T4 and free T4 (FT4)) were measured in all CS at the time of diagnosis and in all CD 3 mon ths after transsphenoidal pituitary tumor resection. Postoperative hormone monitoring within 3 months was conducted in 9 CD patients completing remission. Twenty-eight remitted CD patients experienced hormone and antithyroid antibody evaluation preoperatively and on the 3rd, 6th and 12th month after surgery.
Results: TSH, T3 and FT3 were below the reference range in 31%, 69% and 44% of the 118 CS patients. Remitted CD patients (81/102) had significantly higher TSH (P = 0.000), T3 (P = 0.000) and FT3 (P = 0.000) than those in the non-remission group (21/102). After remission of CD, TSH, T3 and FT3 showed a significant increase, with a few cases above the reference range. By 12 months, most CD patients’ thyroid fu nctions returned to normal. Thyroid hormones (including TSH, T3 and FT3) were negatively associated with serum cortisol levels both before and after surgery. No signific ant changes of antithyroid autoantibodies were observed.
Conclusions: TSH, T3 and FT3 are suppressed in endogenous hypercortisolemia. After remission of CD, TSH, T3 and FT3 increased significantly, even a bove the reference range, but returned to normal 1 year after surgery in most cases. Anti thyroid antibodies did not change significantly after remission of CD.
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topic |
Cushing’s syndrome Cushing’s disease cortisol thyroid hormones antithyroid antibodies |
url |
https://ec.bioscientifica.com/view/journals/ec/8/8/EC-19-0309.xml |
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