Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip
Abstract Objective The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group. Design We investigated femoral heads from 25 patients w...
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doaj-43e7fde41bb943769ca6b0daba6945282020-11-25T03:42:19ZengBMCBMC Musculoskeletal Disorders1471-24742020-10-012111810.1186/s12891-020-03648-wHistomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hipRasmus Klose-Jensen0Andreas Wiggers Nielsen1Louise Brøndt Hartlev2Jesper Skovhus Thomsen3Lene Warner Thorup Boel4Mogens Laursen5Kresten Krarup Keller6Ellen-Margrethe Hauge7Department of Rheumatology, Aarhus University HospitalDepartment of Rheumatology, Aarhus University HospitalDepartment of Rheumatology, Aarhus University HospitalDepartment of Biomedicine – Anatomy, Aarhus UniversityInstitute of Forensic Medicine, Aarhus UniversityOrthopaedic Surgery Research Unit, Aalborg University HospitalDepartment of Rheumatology, Aarhus University HospitalDepartment of Rheumatology, Aarhus University HospitalAbstract Objective The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group. Design We investigated femoral heads from 25 patients with OA following hip replacement surgery, and 25 femoral heads from a control group obtained post-mortem. The area and boundary length of the femoral head, marginal osteophytes, and subarticular osteophytes were determined with histomorphometry. Marginal osteophytes were defined histologically as bony projections at the peripheral margin of the femoral head, while subarticular osteophytes were defined as areas of bone that expanded from the normal curvature of the femoral head into the articular cartilage. Results The prevalence of OA patients with marginal- and subarticular osteophytes were 100 and 84%, respectively. Whereas the prevalence of the participants in the control group with marginal- and subarticular osteophytes were 56 and 28%, respectively. The area and boundary length of marginal osteophytes was (median (Interquartile range)) 165.3mm2 (121.4–254.0) mm2 and 75.1 mm (50.8–99.3) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P < 0.001). For the subarticular osteophytes, the area and boundary length was 1.0 mm2 (0–4.4) mm2 and 1.4 mm (0–6.5) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P < 0.001). Conclusion As expected, both marginal- and subarticular osteophytes at the femoral head, were more frequent and larger in patients with OA than in the control group. However, in the control group, subarticular osteophytes were more prevalent than expected from the minor osteophytic changes at the femoral head margin, which may suggest that subarticular osteophytes are an early degenerative phenomenon that ultimately might develop into clinical osteoarthritis.http://link.springer.com/article/10.1186/s12891-020-03648-wOsteoarthritisFemoral headOsteophytes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rasmus Klose-Jensen Andreas Wiggers Nielsen Louise Brøndt Hartlev Jesper Skovhus Thomsen Lene Warner Thorup Boel Mogens Laursen Kresten Krarup Keller Ellen-Margrethe Hauge |
spellingShingle |
Rasmus Klose-Jensen Andreas Wiggers Nielsen Louise Brøndt Hartlev Jesper Skovhus Thomsen Lene Warner Thorup Boel Mogens Laursen Kresten Krarup Keller Ellen-Margrethe Hauge Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip BMC Musculoskeletal Disorders Osteoarthritis Femoral head Osteophytes |
author_facet |
Rasmus Klose-Jensen Andreas Wiggers Nielsen Louise Brøndt Hartlev Jesper Skovhus Thomsen Lene Warner Thorup Boel Mogens Laursen Kresten Krarup Keller Ellen-Margrethe Hauge |
author_sort |
Rasmus Klose-Jensen |
title |
Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip |
title_short |
Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip |
title_full |
Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip |
title_fullStr |
Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip |
title_full_unstemmed |
Histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip |
title_sort |
histomorphometric case-control study of subarticular osteophytes in patients with osteoarthritis of the hip |
publisher |
BMC |
series |
BMC Musculoskeletal Disorders |
issn |
1471-2474 |
publishDate |
2020-10-01 |
description |
Abstract Objective The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis (OA), and to compare these to that of a control group. Design We investigated femoral heads from 25 patients with OA following hip replacement surgery, and 25 femoral heads from a control group obtained post-mortem. The area and boundary length of the femoral head, marginal osteophytes, and subarticular osteophytes were determined with histomorphometry. Marginal osteophytes were defined histologically as bony projections at the peripheral margin of the femoral head, while subarticular osteophytes were defined as areas of bone that expanded from the normal curvature of the femoral head into the articular cartilage. Results The prevalence of OA patients with marginal- and subarticular osteophytes were 100 and 84%, respectively. Whereas the prevalence of the participants in the control group with marginal- and subarticular osteophytes were 56 and 28%, respectively. The area and boundary length of marginal osteophytes was (median (Interquartile range)) 165.3mm2 (121.4–254.0) mm2 and 75.1 mm (50.8–99.3) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P < 0.001). For the subarticular osteophytes, the area and boundary length was 1.0 mm2 (0–4.4) mm2 and 1.4 mm (0–6.5) mm for patients with OA compared to 0 mm2 (0–0.5) mm2 and 0 mm (0–0.5) mm for the control group (P < 0.001). Conclusion As expected, both marginal- and subarticular osteophytes at the femoral head, were more frequent and larger in patients with OA than in the control group. However, in the control group, subarticular osteophytes were more prevalent than expected from the minor osteophytic changes at the femoral head margin, which may suggest that subarticular osteophytes are an early degenerative phenomenon that ultimately might develop into clinical osteoarthritis. |
topic |
Osteoarthritis Femoral head Osteophytes |
url |
http://link.springer.com/article/10.1186/s12891-020-03648-w |
work_keys_str_mv |
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