The nuclear chaperone nucleophosmin escorts an Epstein-Barr Virus nuclear antigen to establish transcriptional cascades for latent infection in human B cells.
Epstein-Barr Virus (EBV) is an oncogenic γ-herpesvirus that capably establishes both latent and lytic modes of infection in host cells and causes malignant diseases in humans. Nuclear antigen 2 (EBNA2)-mediated transcription of both cellular and viral genes is essential for the establishment and mai...
Main Authors: | Cheng-Der Liu, Ya-Lin Chen, Yi-Li Min, Bo Zhao, Chi-Ping Cheng, Myung-Soo Kang, Shu-Jun Chiu, Elliott Kieff, Chih-Wen Peng |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3521654?pdf=render |
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