Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child
Xeroderma pigmentosum (XP)is a rare inherited skin disorder characterized by a heightened sensitivity to the DNA damaging effects of ultraviolet radiation (UV). The main source of UV is the sun. The symptoms of XP can be seen in any sun-exposed area of the body. The effects are greatest on the skin,...
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doaj-441bdf1e41034b20a0554ce701990d192020-11-24T21:36:35ZengOur Dermatology OnlineNasza Dermatologia Online2081-93902018-04-0192160163Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old childUday Kumar Sonnappa0Aneesh Samayam 1Department of Dermatology MVJ Medical College and Research Hospital, Hoskote Bangalore, India Department of Dermatology MVJ Medical College and Research Hospital, Hoskote Bangalore, India Xeroderma pigmentosum (XP)is a rare inherited skin disorder characterized by a heightened sensitivity to the DNA damaging effects of ultraviolet radiation (UV). The main source of UV is the sun. The symptoms of XP can be seen in any sun-exposed area of the body. The effects are greatest on the skin, the eyelids and the surface of the eyes but the tip of the tongue may also be damaged. In addition, approximately 25% of XP patients also develop abnormalities of the nervous system manifesting as progressive neuro-degeneration with hearing loss. People with XP have a 10,000-fold increased risk for developing skin cancer including basal cell carcinoma, squamous cell carcinoma and melanoma. They also have a 2000-fold increased risk for cancer of the eye and surrounding ocular tissues. These symptoms appear early in life, typically before age 10 years. This case is being presented to highlight the rarity of a case of xeroderma pigmentosum with squamous cell carcinoma in a ten year old child. http://www.odermatol.com/issue-in-html/2018-2-14-xeroderma/Xeroderma pigmentosumSquamous cell carcinoma in a childCarcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Uday Kumar Sonnappa Aneesh Samayam |
spellingShingle |
Uday Kumar Sonnappa Aneesh Samayam Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child Nasza Dermatologia Online Xeroderma pigmentosum Squamous cell carcinoma in a child Carcinoma |
author_facet |
Uday Kumar Sonnappa Aneesh Samayam |
author_sort |
Uday Kumar Sonnappa |
title |
Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child |
title_short |
Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child |
title_full |
Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child |
title_fullStr |
Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child |
title_full_unstemmed |
Case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child |
title_sort |
case report on xeroderma pigmentosum with squamous cell carcinoma in a ten year old child |
publisher |
Our Dermatology Online |
series |
Nasza Dermatologia Online |
issn |
2081-9390 |
publishDate |
2018-04-01 |
description |
Xeroderma pigmentosum (XP)is a rare inherited skin disorder characterized by a heightened sensitivity to the DNA damaging effects of ultraviolet radiation (UV). The main source of UV is the sun. The symptoms of XP can be seen in any sun-exposed area of the body. The effects are greatest on the skin, the eyelids and the surface of the eyes but the tip of the tongue may also be damaged. In addition, approximately 25% of XP patients also develop abnormalities of the nervous system manifesting as progressive neuro-degeneration with hearing loss. People with XP have a 10,000-fold increased risk for developing skin cancer including basal cell carcinoma, squamous cell carcinoma and melanoma. They also have a 2000-fold increased risk for cancer of the eye and surrounding ocular tissues. These symptoms appear early in life, typically before age 10 years. This case is being presented to highlight the rarity of a case of xeroderma pigmentosum with squamous cell carcinoma in a ten year old child. |
topic |
Xeroderma pigmentosum Squamous cell carcinoma in a child Carcinoma |
url |
http://www.odermatol.com/issue-in-html/2018-2-14-xeroderma/ |
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