Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum
In an experiment on white wild-type laboratory rats, it was shown that 90 minutes after intraperitoneal administration of cisplatin at a dose of 4 mg / kg as a solution heated to 43 °C, the integral level of metallothionein significantly increased in the organs. Metallothionein actively binds toxic...
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doaj-4421e11ad30043c8bab8d6401d92e31a2020-11-25T01:41:21ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062018-01-018139139610.5281/zenodo.26520806111Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinumE. D. Pykhtieieva0E. G. Pykhtieieva1A. I. Gozhenko2Ukrainian Research Institute of Transport MedicineUkrainian Research Institute of Transport MedicineUkrainian Research Institute of Transport MedicineIn an experiment on white wild-type laboratory rats, it was shown that 90 minutes after intraperitoneal administration of cisplatin at a dose of 4 mg / kg as a solution heated to 43 °C, the integral level of metallothionein significantly increased in the organs. Metallothionein actively binds toxic compounds of metals, including platinum. This may be one of the main reasons for developing resistance to platinum drugs with repeated courses of chemotherapy. Fast inductive synthesis of MT with the introduction of heavy metal compounds is one of the mechanisms of adaptation of the organism to the introduction of a highly toxic platinum compound. The binding of platinum to the sulfhydryl groups of metallothionein reduces the side effect of cisplatin while simultaneously decreasing its antitumor activity. It is not recommended to use the main metallothionein inducers (Zn, Se, antioxidants) in patients with cisplatin sensitive tumors before chemotherapy courses.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6867cisplatin, kidneys, liver, metallothionein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
E. D. Pykhtieieva E. G. Pykhtieieva A. I. Gozhenko |
spellingShingle |
E. D. Pykhtieieva E. G. Pykhtieieva A. I. Gozhenko Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum Journal of Education, Health and Sport cisplatin, kidneys, liver, metallothionein |
author_facet |
E. D. Pykhtieieva E. G. Pykhtieieva A. I. Gozhenko |
author_sort |
E. D. Pykhtieieva |
title |
Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum |
title_short |
Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum |
title_full |
Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum |
title_fullStr |
Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum |
title_full_unstemmed |
Experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum |
title_sort |
experimental study of metallothionein synthesis in modeling hyperthermic intraoperative intraperitoneal chemoperfusion with cysplatinum |
publisher |
Kazimierz Wielki University |
series |
Journal of Education, Health and Sport |
issn |
2391-8306 |
publishDate |
2018-01-01 |
description |
In an experiment on white wild-type laboratory rats, it was shown that 90 minutes after intraperitoneal administration of cisplatin at a dose of 4 mg / kg as a solution heated to 43 °C, the integral level of metallothionein significantly increased in the organs. Metallothionein actively binds toxic compounds of metals, including platinum. This may be one of the main reasons for developing resistance to platinum drugs with repeated courses of chemotherapy. Fast inductive synthesis of MT with the introduction of heavy metal compounds is one of the mechanisms of adaptation of the organism to the introduction of a highly toxic platinum compound. The binding of platinum to the sulfhydryl groups of metallothionein reduces the side effect of cisplatin while simultaneously decreasing its antitumor activity. It is not recommended to use the main metallothionein inducers (Zn, Se, antioxidants) in patients with cisplatin sensitive tumors before chemotherapy courses. |
topic |
cisplatin, kidneys, liver, metallothionein |
url |
http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6867 |
work_keys_str_mv |
AT edpykhtieieva experimentalstudyofmetallothioneinsynthesisinmodelinghyperthermicintraoperativeintraperitonealchemoperfusionwithcysplatinum AT egpykhtieieva experimentalstudyofmetallothioneinsynthesisinmodelinghyperthermicintraoperativeintraperitonealchemoperfusionwithcysplatinum AT aigozhenko experimentalstudyofmetallothioneinsynthesisinmodelinghyperthermicintraoperativeintraperitonealchemoperfusionwithcysplatinum |
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1725041188639080448 |