Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality
Background: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aime...
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doaj-44246e9dee7840ada71ffa0971c9f1462021-04-13T23:00:32ZengMDPI AGNutrients2072-66432021-04-01131266126610.3390/nu13041266Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of PracticalityHelen L. Barrett0Marloes Dekker Nitert1Michael D’Emden2Barbara Lingwood3Susan de Jersey4H. David McIntyre5Leonie K. Callaway6Mater Research Institute-The University of Queensland, South Brisbane, QLD 4101, AustraliaSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, AustraliaThe Royal Brisbane and Women’s Hospital, Herston, QLD 4029, AustraliaUQ Centre for Clinical Research, The University of Queensland, Herston, QLD 4006, AustraliaThe Royal Brisbane and Women’s Hospital, Herston, QLD 4029, AustraliaMater Research Institute-The University of Queensland, South Brisbane, QLD 4101, AustraliaThe Royal Brisbane and Women’s Hospital, Herston, QLD 4029, AustraliaBackground: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aimed to examine the utility of monitoring capillary triglycerides in women in late pregnancy. Methods: Twenty-nine women (22 with gestational diabetes (GDM) and 7 without) measured capillary glucose and triglycerides using standard meters at home for four days. On two of those days, they consumed one of two standard isocaloric breakfast meals: a high-fat/low-carbohydrate meal (66% fat) or low fat/high carbohydrate meal (10% fat). Following the standard meals, glucose and triglyceride levels were monitored. Results: Median capillary triglycerides were highly variable between women but did not differ between GDM and normoglycaemic women. There was variability in capillary triglycerides over four days of home monitoring and a difference in incremental area under the curve for capillary triglycerides and glucose between the two standard meals. The high-fat standard meal lowered the incremental area under the curve for capillary glucose (<i>p</i> < 0.0001). Fasting (rho 0.66, <i>p</i> = 0.0002) and postpradial capillary triglycerides measured at home correlated with venous triglyceride levels. Conclusions: The lack of differences in response to dietary fat intake and the correlation between capillary and venous triglycerides suggest that monitoring of capillary triglycerides before and after meals in pregnancy is unlikely to be useful in the routine clinical practice management of women with gestational diabetes mellitus.https://www.mdpi.com/2072-6643/13/4/1266capillarygestational diabetesmixed meal testpregnancytriglycerides |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Helen L. Barrett Marloes Dekker Nitert Michael D’Emden Barbara Lingwood Susan de Jersey H. David McIntyre Leonie K. Callaway |
spellingShingle |
Helen L. Barrett Marloes Dekker Nitert Michael D’Emden Barbara Lingwood Susan de Jersey H. David McIntyre Leonie K. Callaway Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality Nutrients capillary gestational diabetes mixed meal test pregnancy triglycerides |
author_facet |
Helen L. Barrett Marloes Dekker Nitert Michael D’Emden Barbara Lingwood Susan de Jersey H. David McIntyre Leonie K. Callaway |
author_sort |
Helen L. Barrett |
title |
Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality |
title_short |
Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality |
title_full |
Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality |
title_fullStr |
Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality |
title_full_unstemmed |
Capillary Triglycerides in Late Pregnancy—Challenging to Measure, Hard to Interpret: A Cohort Study of Practicality |
title_sort |
capillary triglycerides in late pregnancy—challenging to measure, hard to interpret: a cohort study of practicality |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2021-04-01 |
description |
Background: Maternal triglycerides are increasingly recognised as important predictors of infant growth and fat mass. The variability of triglyceride patterns during the day and their relationship to dietary intake in women in late pregnancy have not been explored. This prospective cohort study aimed to examine the utility of monitoring capillary triglycerides in women in late pregnancy. Methods: Twenty-nine women (22 with gestational diabetes (GDM) and 7 without) measured capillary glucose and triglycerides using standard meters at home for four days. On two of those days, they consumed one of two standard isocaloric breakfast meals: a high-fat/low-carbohydrate meal (66% fat) or low fat/high carbohydrate meal (10% fat). Following the standard meals, glucose and triglyceride levels were monitored. Results: Median capillary triglycerides were highly variable between women but did not differ between GDM and normoglycaemic women. There was variability in capillary triglycerides over four days of home monitoring and a difference in incremental area under the curve for capillary triglycerides and glucose between the two standard meals. The high-fat standard meal lowered the incremental area under the curve for capillary glucose (<i>p</i> < 0.0001). Fasting (rho 0.66, <i>p</i> = 0.0002) and postpradial capillary triglycerides measured at home correlated with venous triglyceride levels. Conclusions: The lack of differences in response to dietary fat intake and the correlation between capillary and venous triglycerides suggest that monitoring of capillary triglycerides before and after meals in pregnancy is unlikely to be useful in the routine clinical practice management of women with gestational diabetes mellitus. |
topic |
capillary gestational diabetes mixed meal test pregnancy triglycerides |
url |
https://www.mdpi.com/2072-6643/13/4/1266 |
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