Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.

OBJECTIVE:To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). METHODS:We enrolled laboratory-co...

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Main Authors: Ting-Yu Yen, Wei-Liang Shih, Yi-Chuan Huang, Jian-Te Lee, Li-Min Huang, Luan-Yin Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6218064?pdf=render
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spelling doaj-4439352a0b42413c8c6b4a79bbabac212020-11-25T01:57:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020676910.1371/journal.pone.0206769Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.Ting-Yu YenWei-Liang ShihYi-Chuan HuangJian-Te LeeLi-Min HuangLuan-Yin ChangOBJECTIVE:To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). METHODS:We enrolled laboratory-confirmed EV71 cases and healthy age- and gender-matched controls in Taiwan from 2000 to 2012. We detected genetic polymorphisms in SCARB2, PSGL-1, and ANXA2 and correlated the results with EV71 susceptibility and severity. RESULTS:We collected 599 EV71 cases and 98 controls. Among EV71 patients, the male to female ratio was 1.61, and the mean age was 2.99±2.47 years. For clinical severity, 117 (19.6%) had severe central nervous system involvement with or without cardiopulmonary failure. For outcomes, 46 (7.7%) had sequelae, and 14 (2.3%) died. SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). PSGL-1 polymorphisms (rs7137098 and rs8179137) were significantly associated with severe EV71 infection (OR 1.46, 95% CI 1.1-1.96; and OR 1.47, 95% CI 1.07-2.03, respectively). CONCLUSIONS:SCARB2 polymorphisms (rs6824953 and rs11097262) might be associated with EV71 susceptibility. PSGL-1 polymorphisms (rs7137098 and rs8179137) were associated with severe EV71 infection.http://europepmc.org/articles/PMC6218064?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Ting-Yu Yen
Wei-Liang Shih
Yi-Chuan Huang
Jian-Te Lee
Li-Min Huang
Luan-Yin Chang
spellingShingle Ting-Yu Yen
Wei-Liang Shih
Yi-Chuan Huang
Jian-Te Lee
Li-Min Huang
Luan-Yin Chang
Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
PLoS ONE
author_facet Ting-Yu Yen
Wei-Liang Shih
Yi-Chuan Huang
Jian-Te Lee
Li-Min Huang
Luan-Yin Chang
author_sort Ting-Yu Yen
title Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
title_short Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
title_full Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
title_fullStr Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
title_full_unstemmed Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
title_sort polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2018-01-01
description OBJECTIVE:To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). METHODS:We enrolled laboratory-confirmed EV71 cases and healthy age- and gender-matched controls in Taiwan from 2000 to 2012. We detected genetic polymorphisms in SCARB2, PSGL-1, and ANXA2 and correlated the results with EV71 susceptibility and severity. RESULTS:We collected 599 EV71 cases and 98 controls. Among EV71 patients, the male to female ratio was 1.61, and the mean age was 2.99±2.47 years. For clinical severity, 117 (19.6%) had severe central nervous system involvement with or without cardiopulmonary failure. For outcomes, 46 (7.7%) had sequelae, and 14 (2.3%) died. SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). PSGL-1 polymorphisms (rs7137098 and rs8179137) were significantly associated with severe EV71 infection (OR 1.46, 95% CI 1.1-1.96; and OR 1.47, 95% CI 1.07-2.03, respectively). CONCLUSIONS:SCARB2 polymorphisms (rs6824953 and rs11097262) might be associated with EV71 susceptibility. PSGL-1 polymorphisms (rs7137098 and rs8179137) were associated with severe EV71 infection.
url http://europepmc.org/articles/PMC6218064?pdf=render
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