Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.
OBJECTIVE:To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). METHODS:We enrolled laboratory-co...
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doaj-4439352a0b42413c8c6b4a79bbabac212020-11-25T01:57:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011311e020676910.1371/journal.pone.0206769Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity.Ting-Yu YenWei-Liang ShihYi-Chuan HuangJian-Te LeeLi-Min HuangLuan-Yin ChangOBJECTIVE:To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). METHODS:We enrolled laboratory-confirmed EV71 cases and healthy age- and gender-matched controls in Taiwan from 2000 to 2012. We detected genetic polymorphisms in SCARB2, PSGL-1, and ANXA2 and correlated the results with EV71 susceptibility and severity. RESULTS:We collected 599 EV71 cases and 98 controls. Among EV71 patients, the male to female ratio was 1.61, and the mean age was 2.99±2.47 years. For clinical severity, 117 (19.6%) had severe central nervous system involvement with or without cardiopulmonary failure. For outcomes, 46 (7.7%) had sequelae, and 14 (2.3%) died. SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). PSGL-1 polymorphisms (rs7137098 and rs8179137) were significantly associated with severe EV71 infection (OR 1.46, 95% CI 1.1-1.96; and OR 1.47, 95% CI 1.07-2.03, respectively). CONCLUSIONS:SCARB2 polymorphisms (rs6824953 and rs11097262) might be associated with EV71 susceptibility. PSGL-1 polymorphisms (rs7137098 and rs8179137) were associated with severe EV71 infection.http://europepmc.org/articles/PMC6218064?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting-Yu Yen Wei-Liang Shih Yi-Chuan Huang Jian-Te Lee Li-Min Huang Luan-Yin Chang |
spellingShingle |
Ting-Yu Yen Wei-Liang Shih Yi-Chuan Huang Jian-Te Lee Li-Min Huang Luan-Yin Chang Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. PLoS ONE |
author_facet |
Ting-Yu Yen Wei-Liang Shih Yi-Chuan Huang Jian-Te Lee Li-Min Huang Luan-Yin Chang |
author_sort |
Ting-Yu Yen |
title |
Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. |
title_short |
Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. |
title_full |
Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. |
title_fullStr |
Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. |
title_full_unstemmed |
Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. |
title_sort |
polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
OBJECTIVE:To evaluate the association of enterovirus 71 (EV71) susceptibility and clinical severity with polymorphisms in EV71 receptors, including human scavenger receptor class B member 2 (SCARB2), P-selectin glycoprotein ligand-1 (PSGL-1), and annexin II (ANXA2). METHODS:We enrolled laboratory-confirmed EV71 cases and healthy age- and gender-matched controls in Taiwan from 2000 to 2012. We detected genetic polymorphisms in SCARB2, PSGL-1, and ANXA2 and correlated the results with EV71 susceptibility and severity. RESULTS:We collected 599 EV71 cases and 98 controls. Among EV71 patients, the male to female ratio was 1.61, and the mean age was 2.99±2.47 years. For clinical severity, 117 (19.6%) had severe central nervous system involvement with or without cardiopulmonary failure. For outcomes, 46 (7.7%) had sequelae, and 14 (2.3%) died. SCARB2 polymorphisms (rs6824953 and rs11097262) were associated with susceptibility to EV71 infection (OR 1.60, 95% CI 1.07-2.39; and OR 1.64, 95% CI 1.09-2.47, respectively). PSGL-1 polymorphisms (rs7137098 and rs8179137) were significantly associated with severe EV71 infection (OR 1.46, 95% CI 1.1-1.96; and OR 1.47, 95% CI 1.07-2.03, respectively). CONCLUSIONS:SCARB2 polymorphisms (rs6824953 and rs11097262) might be associated with EV71 susceptibility. PSGL-1 polymorphisms (rs7137098 and rs8179137) were associated with severe EV71 infection. |
url |
http://europepmc.org/articles/PMC6218064?pdf=render |
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