A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer.

A comprehensive investigation on common polymorphisms in the MDR1/ABCB1 transporter gene and susceptibility to colorectal cancer.

ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved in the elimination of several carcinogens from the gut. Several polymorphic variants within the ABCB1 gene have been reported as modulators of ABCB1-mediated transport. We investigated the impact of ABCB1 ge...

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Main Authors: Daniele Campa, Juan Sainz, Barbara Pardini, Ludmila Vodickova, Alessio Naccarati, Anja Rudolph, Jan Novotny, Asta Försti, Stephan Buch, Witigo von Schönfels, Clemens Schafmayer, Henry Völzke, Michael Hoffmeister, Bernd Frank, Roberto Barale, Kari Hemminki, Jochen Hampe, Jenny Chang-Claude, Hermann Brenner, Pavel Vodicka, Federico Canzian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22396794/pdf/?tool=EBI

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