Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Abstract Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were eval...

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Main Authors:	Xin Wei, Afsar Khan, Da Song, Zhi Dai, Ya-Ping Liu, Hao-Fei Yu, Bei Wang, Pei-Feng Zhu, Cai-Feng Ding, Xu-Dong Zhao, Yi-Fen Wang, Xiao-Dong Luo
Format:	Article
Language:	English
Published:	SpringerOpen 2017-06-01
Series:	Natural Products and Bioprospecting
Subjects:	Vinca major Apocynaceae Pyridine alkaloids Cytotoxicity
Online Access:	http://link.springer.com/article/10.1007/s13659-017-0137-7

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spelling	doaj-444499b68b644394a7e9d664f11830912020-11-25T00:39:57ZengSpringerOpenNatural Products and Bioprospecting2192-21952192-22092017-06-017432332710.1007/s13659-017-0137-7Three New Pyridine Alkaloids from Vinca major Cultivated in PakistanXin Wei0Afsar Khan1Da Song2Zhi Dai3Ya-Ping Liu4Hao-Fei Yu5Bei Wang6Pei-Feng Zhu7Cai-Feng Ding8Xu-Dong Zhao9Yi-Fen Wang10Xiao-Dong Luo11State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesYunnan College of Business ManagementKey Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesState Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of SciencesAbstract Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3# and GITC-18#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.http://link.springer.com/article/10.1007/s13659-017-0137-7Vinca majorApocynaceaePyridine alkaloidsCytotoxicity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xin Wei Afsar Khan Da Song Zhi Dai Ya-Ping Liu Hao-Fei Yu Bei Wang Pei-Feng Zhu Cai-Feng Ding Xu-Dong Zhao Yi-Fen Wang Xiao-Dong Luo
spellingShingle	Xin Wei Afsar Khan Da Song Zhi Dai Ya-Ping Liu Hao-Fei Yu Bei Wang Pei-Feng Zhu Cai-Feng Ding Xu-Dong Zhao Yi-Fen Wang Xiao-Dong Luo Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan Natural Products and Bioprospecting Vinca major Apocynaceae Pyridine alkaloids Cytotoxicity
author_facet	Xin Wei Afsar Khan Da Song Zhi Dai Ya-Ping Liu Hao-Fei Yu Bei Wang Pei-Feng Zhu Cai-Feng Ding Xu-Dong Zhao Yi-Fen Wang Xiao-Dong Luo
author_sort	Xin Wei
title	Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
title_short	Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
title_full	Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
title_fullStr	Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
title_full_unstemmed	Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan
title_sort	three new pyridine alkaloids from vinca major cultivated in pakistan
publisher	SpringerOpen
series	Natural Products and Bioprospecting
issn	2192-2195 2192-2209
publishDate	2017-06-01
description	Abstract Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3# and GITC-18#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.
topic	Vinca major Apocynaceae Pyridine alkaloids Cytotoxicity
url	http://link.springer.com/article/10.1007/s13659-017-0137-7
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Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

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