Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host ti...
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doaj-44475b35ba474e9588df36d343c83d8b2020-11-24T23:43:30ZengBMCBiological Research0716-97600717-62872011-01-014415361Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunityCarolina LlanosLeandro J CarreñoAlexis M KalergisUnder healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell function. Therefore, because DCs work as central modulators of immune tolerance, it is likely that alterations in their function can lead to the onset of autoimmune-inflammatory diseases. By modulating DC function, novel pathways in antigen-specific tolerance could be established. In this article, the possible contribution of altered DC-T cell interactions to the onset of autoimmunity are discussed. In addition, we expand on the notion that some of the functions of these cells could be relevant targets for intervening therapies aimed to restore the balance or even prevent the loss of tolerance.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007dendritic cellsT cellsimmunological synapseautoimmunitytolerance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carolina Llanos Leandro J Carreño Alexis M Kalergis |
spellingShingle |
Carolina Llanos Leandro J Carreño Alexis M Kalergis Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity Biological Research dendritic cells T cells immunological synapse autoimmunity tolerance |
author_facet |
Carolina Llanos Leandro J Carreño Alexis M Kalergis |
author_sort |
Carolina Llanos |
title |
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity |
title_short |
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity |
title_full |
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity |
title_fullStr |
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity |
title_full_unstemmed |
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity |
title_sort |
contribution of dendritic cell/t cell interactions to triggering and maintaining autoimmunity |
publisher |
BMC |
series |
Biological Research |
issn |
0716-9760 0717-6287 |
publishDate |
2011-01-01 |
description |
Under healthy conditions, there is a balance between tolerance to self-tissue constituents and immunity against foreign antigens. Autoimmunity diseases (AD) take place when that equilibrium is disrupted and the immune response is directed to self-antigens, leading to injury or destruction of host tissues. The mechanisms conducing to the loss of immune tolerance remain largely unknown. The recent appearance of biological therapies has contributed to significant reduction in morbidity. However, currently available therapies are associated with important side effects and work only as palliative treatments. Dendritic cells (DCs) have emerged as key players in developing and maintaining adaptive immunity due to their capacity to prime and modulate T cell function. Therefore, because DCs work as central modulators of immune tolerance, it is likely that alterations in their function can lead to the onset of autoimmune-inflammatory diseases. By modulating DC function, novel pathways in antigen-specific tolerance could be established. In this article, the possible contribution of altered DC-T cell interactions to the onset of autoimmunity are discussed. In addition, we expand on the notion that some of the functions of these cells could be relevant targets for intervening therapies aimed to restore the balance or even prevent the loss of tolerance. |
topic |
dendritic cells T cells immunological synapse autoimmunity tolerance |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100007 |
work_keys_str_mv |
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