Pharmacological Inhibition of p38 MAPK by SB203580 Increases Resistance to Carboplatin in A2780cp Cells and Promotes Growth in Primary Ovarian Cancer Cells

Pharmacological Inhibition of p38 MAPK by SB203580 Increases Resistance to Carboplatin in A2780cp Cells and Promotes Growth in Primary Ovarian Cancer Cells

Chemoresistance renders current chemotherapy regimens ineffective against advanced epithelial ovarian cancer (EOC). Carboplatin (the first-line chemotherapeutic agent to treat EOC) induces cell death by regulating multiple signaling pathways. The objective of this study is to identify the signaling...

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Bibliographic Details
Main Authors: Xiaolu Han, Huachen Chen, Jiesi Zhou, Helen Steed, Lynne-Marie Postovit, YangXin Fu
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
epithelial ovarian cancer
chemoresistance
carboplatin
p38 MAPK
primary EOC cells
surviving
Online Access:http://www.mdpi.com/1422-0067/19/8/2184

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