Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation
Seven polyoxazoline ligands were synthesized in high yield in a one-pot reaction by heating polycarboxylic acids or their esters and chiral β-amino alcohols under reflux with concomitant removal of water or the alcohol produced in the reaction. The method is much simpler and more efficient in compar...
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doaj-445afaeebbf94132b7c0a052029970702021-02-02T03:34:54ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972010-03-01612910.3762/bjoc.6.291860-5397-6-29Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylationWei Jie Li0Zun Le Xu1Sheng Xiang Qiu2Program for Natural Product Chemical Biology & Drug Discovery, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, ChinaDepartment of Applied Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Haizhou District, Guangzhou 510275, ChinaProgram for Natural Product Chemical Biology & Drug Discovery, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, ChinaSeven polyoxazoline ligands were synthesized in high yield in a one-pot reaction by heating polycarboxylic acids or their esters and chiral β-amino alcohols under reflux with concomitant removal of water or the alcohol produced in the reaction. The method is much simpler and more efficient in comparison to those methods reported in the literature.The compounds were used as chiral ligands in the rhodium-catalyzed asymmetric hydrosilylation of aromatic ketones, and the effects of the linkers and the substituents present on the oxazoline rings on the yield and enantioselectivity investigated. Compound 2 was identified as the best ligand of this family for the hydrosilylation of aromatic ketones.https://doi.org/10.3762/bjoc.6.29aromatic ketonehydrosilylationpolyoxazolinerhodiumsynthesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei Jie Li Zun Le Xu Sheng Xiang Qiu |
spellingShingle |
Wei Jie Li Zun Le Xu Sheng Xiang Qiu Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation Beilstein Journal of Organic Chemistry aromatic ketone hydrosilylation polyoxazoline rhodium synthesis |
author_facet |
Wei Jie Li Zun Le Xu Sheng Xiang Qiu |
author_sort |
Wei Jie Li |
title |
Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation |
title_short |
Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation |
title_full |
Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation |
title_fullStr |
Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation |
title_full_unstemmed |
Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation |
title_sort |
concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation |
publisher |
Beilstein-Institut |
series |
Beilstein Journal of Organic Chemistry |
issn |
1860-5397 |
publishDate |
2010-03-01 |
description |
Seven polyoxazoline ligands were synthesized in high yield in a one-pot reaction by heating polycarboxylic acids or their esters and chiral β-amino alcohols under reflux with concomitant removal of water or the alcohol produced in the reaction. The method is much simpler and more efficient in comparison to those methods reported in the literature.The compounds were used as chiral ligands in the rhodium-catalyzed asymmetric hydrosilylation of aromatic ketones, and the effects of the linkers and the substituents present on the oxazoline rings on the yield and enantioselectivity investigated. Compound 2 was identified as the best ligand of this family for the hydrosilylation of aromatic ketones. |
topic |
aromatic ketone hydrosilylation polyoxazoline rhodium synthesis |
url |
https://doi.org/10.3762/bjoc.6.29 |
work_keys_str_mv |
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