The susceptibility of adult schistosomes to immune attrition
Mouse infection models are described that demonstrate reduction of egg production in Schistosoma haematobium infections and both worm loss and reduced fecundity in S. bovis infections. Neither phenomenum could be shown in S. mansoni infected mice. The immunological basis for these anti-adult respons...
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Instituto Oswaldo Cruz, Ministério da Saúde
1992-01-01
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doaj-445b3a53d96a4ab78f50a5138c5a2b9f2020-11-24T23:57:10ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80601992-01-0187879310.1590/S0074-02761992000800012The susceptibility of adult schistosomes to immune attritionA. M. AgnewH. M. MurareS. Navarrete SandovalN. de JongF. W. KrijerA. M. DeelderM. J. DoenhoffMouse infection models are described that demonstrate reduction of egg production in Schistosoma haematobium infections and both worm loss and reduced fecundity in S. bovis infections. Neither phenomenum could be shown in S. mansoni infected mice. The immunological basis for these anti-adult responses was inferred by comparison with infections in T-cell deprived mice and by the serum transfer of the ability to reduce a S. bovis worm burden into immunocompromised hosts. Vaccination with irradiation attenuated parasites was also shown to have consequences for the adults of a challenge infections of S. haematobium and S. bovis specifically. Prior vaccination resulted in an abrogation of the anti-fecundity and adult worm elimination that occurred in non-vaccinated similary infected mice. hese models are being used to define the targets and mechanisms involved in anti-adult attrition. A serological assay, quantitation of a circulating antigen (CAA) has been assessed for its ability to measure worm burdens of different species of schistosome in mice. This assay will be used to question whether anti-adult immunity contributes to the pattern of infection with S. mansoni and S. haematobium in man.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800012Schistosoma haematobiumSchistosoma bovisSchistosoma mansoniimmunitymouseadultlarvaGST28circulating antigenworm fecundity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. M. Agnew H. M. Murare S. Navarrete Sandoval N. de Jong F. W. Krijer A. M. Deelder M. J. Doenhoff |
spellingShingle |
A. M. Agnew H. M. Murare S. Navarrete Sandoval N. de Jong F. W. Krijer A. M. Deelder M. J. Doenhoff The susceptibility of adult schistosomes to immune attrition Memórias do Instituto Oswaldo Cruz. Schistosoma haematobium Schistosoma bovis Schistosoma mansoni immunity mouse adult larva GST28 circulating antigen worm fecundity |
author_facet |
A. M. Agnew H. M. Murare S. Navarrete Sandoval N. de Jong F. W. Krijer A. M. Deelder M. J. Doenhoff |
author_sort |
A. M. Agnew |
title |
The susceptibility of adult schistosomes to immune attrition |
title_short |
The susceptibility of adult schistosomes to immune attrition |
title_full |
The susceptibility of adult schistosomes to immune attrition |
title_fullStr |
The susceptibility of adult schistosomes to immune attrition |
title_full_unstemmed |
The susceptibility of adult schistosomes to immune attrition |
title_sort |
susceptibility of adult schistosomes to immune attrition |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
1992-01-01 |
description |
Mouse infection models are described that demonstrate reduction of egg production in Schistosoma haematobium infections and both worm loss and reduced fecundity in S. bovis infections. Neither phenomenum could be shown in S. mansoni infected mice. The immunological basis for these anti-adult responses was inferred by comparison with infections in T-cell deprived mice and by the serum transfer of the ability to reduce a S. bovis worm burden into immunocompromised hosts. Vaccination with irradiation attenuated parasites was also shown to have consequences for the adults of a challenge infections of S. haematobium and S. bovis specifically. Prior vaccination resulted in an abrogation of the anti-fecundity and adult worm elimination that occurred in non-vaccinated similary infected mice. hese models are being used to define the targets and mechanisms involved in anti-adult attrition. A serological assay, quantitation of a circulating antigen (CAA) has been assessed for its ability to measure worm burdens of different species of schistosome in mice. This assay will be used to question whether anti-adult immunity contributes to the pattern of infection with S. mansoni and S. haematobium in man. |
topic |
Schistosoma haematobium Schistosoma bovis Schistosoma mansoni immunity mouse adult larva GST28 circulating antigen worm fecundity |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800012 |
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