Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment
Many toxic substances in the workplace can modify human health and quality of life and there is still insufficient data on respiratory outcomes in adults exposed to phthalates. The aim of this work was to assess in waste management workers from the Nitra region of Slovakia (n = 30) the extent of exp...
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doaj-4465b518a2cd4c6ab9019bbb779969f32020-11-24T23:00:44ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012014-05-011165628563910.3390/ijerph110605628ijerph110605628Phthalate Exposure and Health-Related Outcomes in Specific Types of Work EnvironmentBranislav Kolena0Ida Petrovicova1Tomas Pilka2Zuzana Pucherova3Michal Munk4Bohumil Matula5Viera Vankova6Peter Petlus7Zita Jenisova8Zdenka Rozova9Sona Wimmerova10Tomas Trnovec11Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Ecology and Environmentalistics, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Informatics, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaSpecialized Hospital of St. Zoerardus Zobor, 949 88 Nitra, SlovakiaDepartment of Ecology and Environmentalistics, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Ecology and Environmentalistics, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Chemistry, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaDepartment of Ecology and Environmentalistics, Constantine the Philosopher University in Nitra, 949 74 Nitra, SlovakiaInstitute of Biophysics, Informatics and Biostatistics, Slovak Medical University, 833 03 Bratislava, SlovakiaDepartment of Environmental Medicine, Slovak Medical University, 833 03 Bratislava, SlovakiaMany toxic substances in the workplace can modify human health and quality of life and there is still insufficient data on respiratory outcomes in adults exposed to phthalates. The aim of this work was to assess in waste management workers from the Nitra region of Slovakia (n = 30) the extent of exposure to phthalates and health-related outcomes. Four urinary phthalate metabolites mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MnBP), monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were determined by high-performance liquid chromatography with mass spectrometry (HPLC-MS/MS). Urinary concentration of MEHP was positively associated with ratio of forced expiratory volume in 1 s to forced vital capacity % (FEV1/FVC) (r = 0.431; p = 0.018) and MiNP with fat free mass index (FFMI) (r = 0.439; p = 0.015). The strongest predictor of pulmonary function was the pack/year index as smoking history that predicted a decrease of pulmonary parameters, the FEV1/FVC, % of predicted values of peak expiratory flow (PEF % of PV) and FEV1 % of PV. Unexpectedly, urinary MEHP and MINP were positively associated with pulmonary function expressed as PEF % of PV and FEV1/FVC. We hypothesize that occupational exposure to phthalates estimated from urinary metabolites (MEHP, MiNP) can modify pulmonary function on top of lifestyle factors.http://www.mdpi.com/1660-4601/11/6/5628urinary phthalate metabolitesoccupational exposurepulmonary functionsanthropometry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Branislav Kolena Ida Petrovicova Tomas Pilka Zuzana Pucherova Michal Munk Bohumil Matula Viera Vankova Peter Petlus Zita Jenisova Zdenka Rozova Sona Wimmerova Tomas Trnovec |
spellingShingle |
Branislav Kolena Ida Petrovicova Tomas Pilka Zuzana Pucherova Michal Munk Bohumil Matula Viera Vankova Peter Petlus Zita Jenisova Zdenka Rozova Sona Wimmerova Tomas Trnovec Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment International Journal of Environmental Research and Public Health urinary phthalate metabolites occupational exposure pulmonary functions anthropometry |
author_facet |
Branislav Kolena Ida Petrovicova Tomas Pilka Zuzana Pucherova Michal Munk Bohumil Matula Viera Vankova Peter Petlus Zita Jenisova Zdenka Rozova Sona Wimmerova Tomas Trnovec |
author_sort |
Branislav Kolena |
title |
Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment |
title_short |
Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment |
title_full |
Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment |
title_fullStr |
Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment |
title_full_unstemmed |
Phthalate Exposure and Health-Related Outcomes in Specific Types of Work Environment |
title_sort |
phthalate exposure and health-related outcomes in specific types of work environment |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2014-05-01 |
description |
Many toxic substances in the workplace can modify human health and quality of life and there is still insufficient data on respiratory outcomes in adults exposed to phthalates. The aim of this work was to assess in waste management workers from the Nitra region of Slovakia (n = 30) the extent of exposure to phthalates and health-related outcomes. Four urinary phthalate metabolites mono(2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MnBP), monoethyl phthalate (MEP) and monoisononyl phthalate (MiNP) were determined by high-performance liquid chromatography with mass spectrometry (HPLC-MS/MS). Urinary concentration of MEHP was positively associated with ratio of forced expiratory volume in 1 s to forced vital capacity % (FEV1/FVC) (r = 0.431; p = 0.018) and MiNP with fat free mass index (FFMI) (r = 0.439; p = 0.015). The strongest predictor of pulmonary function was the pack/year index as smoking history that predicted a decrease of pulmonary parameters, the FEV1/FVC, % of predicted values of peak expiratory flow (PEF % of PV) and FEV1 % of PV. Unexpectedly, urinary MEHP and MINP were positively associated with pulmonary function expressed as PEF % of PV and FEV1/FVC. We hypothesize that occupational exposure to phthalates estimated from urinary metabolites (MEHP, MiNP) can modify pulmonary function on top of lifestyle factors. |
topic |
urinary phthalate metabolites occupational exposure pulmonary functions anthropometry |
url |
http://www.mdpi.com/1660-4601/11/6/5628 |
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