How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy
<i>Objective:</i> Overall mortality is a relevant indicator of the population burden during an epidemic. It informs on both undiagnosed cases and on the effects of health system disruption. <i>Methods:</i> We aimed at evaluating the extent of the total death excess during the...
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doaj-4466a4ca1b3b4e44bb4ccc7a16c652d32020-11-25T02:18:35ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012020-05-01173452345210.3390/ijerph17103452How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in ItalyCorrado Magnani0Danila Azzolina1Elisa Gallo2Daniela Ferrante3Dario Gregori4Unit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, I-28100 Novara, ItalyUnit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, I-28100 Novara, ItalyCovid19ita Study Group, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, I-35131 Padova, ItalyUnit of Medical Statistics and Cancer Epidemiology, Department of Translational Medicine, University of Eastern Piedmont, Novara, and CPO-Piedmont, I-28100 Novara, ItalyCovid19ita Study Group, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padova, I-35131 Padova, Italy<i>Objective:</i> Overall mortality is a relevant indicator of the population burden during an epidemic. It informs on both undiagnosed cases and on the effects of health system disruption. <i>Methods:</i> We aimed at evaluating the extent of the total death excess during the COVID-19 epidemic in Italy. Data from 4433 municipalities providing mortality reports until April 15th, 2020 were included for a total of 34.5 million residents from all Italian regions. Data were analyzed by region, sex and age, and compared to expected from 2015–2019. <i>Results:</i> In both genders, overall mortality was stable until February 2020 and abruptly increased from March 1st onwards. Within the municipalities studied, 77,339 deaths were observed in the period between March 1st to April 15th, 2020, in contrast to the 50,822.6 expected. The rate ratio was 1.11 before age 60 and 1.55 afterwards. Both sexes were affected. The excess was greater in the regions most affected by COVID-19 but always exceeded the deaths attributed to COVID-19. The extrapolation to the total Italian population suggests an excess of 45,033 deaths in the study period, while the number of COVID–19 deaths was 21,046. <i>Conclusion:</i> Our paper shows a large death excess during the COVID-19 epidemic in Italy; greater than the number attributed to it. Possible causes included both the undetected cases and the disruption of the Health Service organization. Timely monitoring of overall mortality based on unbiased nationwide data is an essential tool for epidemic control.https://www.mdpi.com/1660-4601/17/10/3452SARS-CoV-2COVID-19 epidemicmortalitynational statisticsItaly |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Corrado Magnani Danila Azzolina Elisa Gallo Daniela Ferrante Dario Gregori |
spellingShingle |
Corrado Magnani Danila Azzolina Elisa Gallo Daniela Ferrante Dario Gregori How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy International Journal of Environmental Research and Public Health SARS-CoV-2 COVID-19 epidemic mortality national statistics Italy |
author_facet |
Corrado Magnani Danila Azzolina Elisa Gallo Daniela Ferrante Dario Gregori |
author_sort |
Corrado Magnani |
title |
How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy |
title_short |
How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy |
title_full |
How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy |
title_fullStr |
How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy |
title_full_unstemmed |
How Large Was the Mortality Increase Directly and Indirectly Caused by the COVID-19 Epidemic? An Analysis on All-Causes Mortality Data in Italy |
title_sort |
how large was the mortality increase directly and indirectly caused by the covid-19 epidemic? an analysis on all-causes mortality data in italy |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2020-05-01 |
description |
<i>Objective:</i> Overall mortality is a relevant indicator of the population burden during an epidemic. It informs on both undiagnosed cases and on the effects of health system disruption. <i>Methods:</i> We aimed at evaluating the extent of the total death excess during the COVID-19 epidemic in Italy. Data from 4433 municipalities providing mortality reports until April 15th, 2020 were included for a total of 34.5 million residents from all Italian regions. Data were analyzed by region, sex and age, and compared to expected from 2015–2019. <i>Results:</i> In both genders, overall mortality was stable until February 2020 and abruptly increased from March 1st onwards. Within the municipalities studied, 77,339 deaths were observed in the period between March 1st to April 15th, 2020, in contrast to the 50,822.6 expected. The rate ratio was 1.11 before age 60 and 1.55 afterwards. Both sexes were affected. The excess was greater in the regions most affected by COVID-19 but always exceeded the deaths attributed to COVID-19. The extrapolation to the total Italian population suggests an excess of 45,033 deaths in the study period, while the number of COVID–19 deaths was 21,046. <i>Conclusion:</i> Our paper shows a large death excess during the COVID-19 epidemic in Italy; greater than the number attributed to it. Possible causes included both the undetected cases and the disruption of the Health Service organization. Timely monitoring of overall mortality based on unbiased nationwide data is an essential tool for epidemic control. |
topic |
SARS-CoV-2 COVID-19 epidemic mortality national statistics Italy |
url |
https://www.mdpi.com/1660-4601/17/10/3452 |
work_keys_str_mv |
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