Genetic variants associated with platelet count are predictive of human disease and physiological markers

Genetic variants associated with platelet count are predictive of human disease and physiological markers

Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hype...

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Main Authors: Evgenia Mikaelsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gisli Halldorsson, Jon K. Sigurdsson, Sigrun H. Lund, Vinicius Tragante, Pall Melsted, Solvi Rognvaldsson, Kristjan Norland, Anna Helgadottir, Magnus K. Magnusson, Gunnar B. Ragnarsson, Sigurdur Y. Kristinsson, Sigrun Reykdal, Brynjar Vidarsson, Ingibjorg J. Gudmundsdottir, Isleifur Olafsson, Pall T. Onundarson, Olof Sigurdardottir, Emil L. Sigurdsson, Gerdur Grondal, Arni J. Geirsson, Gudmundur Geirsson, Julius Gudmundsson, Hilma Holm, Saedis Saevarsdottir, Ingileif Jonsdottir, Gudmundur Thorgeirsson, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Kari Stefansson
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02642-9
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spelling doaj-446745dde7124b9185d8624ab82cb8ce2021-10-03T11:15:28ZengNature Publishing GroupCommunications Biology2399-36422021-09-014111310.1038/s42003-021-02642-9Genetic variants associated with platelet count are predictive of human disease and physiological markersEvgenia Mikaelsdottir0Gudmar Thorleifsson1Lilja Stefansdottir2Gisli Halldorsson3Jon K. Sigurdsson4Sigrun H. Lund5Vinicius Tragante6Pall Melsted7Solvi Rognvaldsson8Kristjan Norland9Anna Helgadottir10Magnus K. Magnusson11Gunnar B. Ragnarsson12Sigurdur Y. Kristinsson13Sigrun Reykdal14Brynjar Vidarsson15Ingibjorg J. Gudmundsdottir16Isleifur Olafsson17Pall T. Onundarson18Olof Sigurdardottir19Emil L. Sigurdsson20Gerdur Grondal21Arni J. Geirsson22Gudmundur Geirsson23Julius Gudmundsson24Hilma Holm25Saedis Saevarsdottir26Ingileif Jonsdottir27Gudmundur Thorgeirsson28Daniel F. Gudbjartsson29Unnur Thorsteinsdottir30Thorunn Rafnar31Kari Stefansson32deCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgenDepartment of Oncology, Landspitali-University HospitalFaculty of Medicine, University of IcelandDepartment of Hematology, Landspitali-University HospitalDepartment of Hematology, Landspitali-University HospitalDepartment of Cardiology, Landspitali-University HospitalDepartment of Clinical Biochemistry, Landspitali-University HospitalFaculty of Medicine, University of IcelandDepartment of Clinical Biochemistry, Akureyri HospitalDevelopment Centre for the Primary CareDepartment of Rheumatology, Landspitali-University HospitalDepartment of Rheumatology, Landspitali-University HospitalDepartment of Urology, Landspitali-University HospitaldeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgenEvgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.https://doi.org/10.1038/s42003-021-02642-9
collection DOAJ
language English
format Article
sources DOAJ
author Evgenia Mikaelsdottir
Gudmar Thorleifsson
Lilja Stefansdottir
Gisli Halldorsson
Jon K. Sigurdsson
Sigrun H. Lund
Vinicius Tragante
Pall Melsted
Solvi Rognvaldsson
Kristjan Norland
Anna Helgadottir
Magnus K. Magnusson
Gunnar B. Ragnarsson
Sigurdur Y. Kristinsson
Sigrun Reykdal
Brynjar Vidarsson
Ingibjorg J. Gudmundsdottir
Isleifur Olafsson
Pall T. Onundarson
Olof Sigurdardottir
Emil L. Sigurdsson
Gerdur Grondal
Arni J. Geirsson
Gudmundur Geirsson
Julius Gudmundsson
Hilma Holm
Saedis Saevarsdottir
Ingileif Jonsdottir
Gudmundur Thorgeirsson
Daniel F. Gudbjartsson
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson
spellingShingle Evgenia Mikaelsdottir
Gudmar Thorleifsson
Lilja Stefansdottir
Gisli Halldorsson
Jon K. Sigurdsson
Sigrun H. Lund
Vinicius Tragante
Pall Melsted
Solvi Rognvaldsson
Kristjan Norland
Anna Helgadottir
Magnus K. Magnusson
Gunnar B. Ragnarsson
Sigurdur Y. Kristinsson
Sigrun Reykdal
Brynjar Vidarsson
Ingibjorg J. Gudmundsdottir
Isleifur Olafsson
Pall T. Onundarson
Olof Sigurdardottir
Emil L. Sigurdsson
Gerdur Grondal
Arni J. Geirsson
Gudmundur Geirsson
Julius Gudmundsson
Hilma Holm
Saedis Saevarsdottir
Ingileif Jonsdottir
Gudmundur Thorgeirsson
Daniel F. Gudbjartsson
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson
Genetic variants associated with platelet count are predictive of human disease and physiological markers
Communications Biology
author_facet Evgenia Mikaelsdottir
Gudmar Thorleifsson
Lilja Stefansdottir
Gisli Halldorsson
Jon K. Sigurdsson
Sigrun H. Lund
Vinicius Tragante
Pall Melsted
Solvi Rognvaldsson
Kristjan Norland
Anna Helgadottir
Magnus K. Magnusson
Gunnar B. Ragnarsson
Sigurdur Y. Kristinsson
Sigrun Reykdal
Brynjar Vidarsson
Ingibjorg J. Gudmundsdottir
Isleifur Olafsson
Pall T. Onundarson
Olof Sigurdardottir
Emil L. Sigurdsson
Gerdur Grondal
Arni J. Geirsson
Gudmundur Geirsson
Julius Gudmundsson
Hilma Holm
Saedis Saevarsdottir
Ingileif Jonsdottir
Gudmundur Thorgeirsson
Daniel F. Gudbjartsson
Unnur Thorsteinsdottir
Thorunn Rafnar
Kari Stefansson
author_sort Evgenia Mikaelsdottir
title Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_short Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_full Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_fullStr Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_full_unstemmed Genetic variants associated with platelet count are predictive of human disease and physiological markers
title_sort genetic variants associated with platelet count are predictive of human disease and physiological markers
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-09-01
description Evgenia Mikaelsdottir et al. report a study of variants associated with platelet count among European individuals where they identify 577 associations. They also report a genetic overlap between platelet count and human diseases, including myeloproliferative neoplasms, rheumatoid arthritis, and hypertension, as well as a genetic overlap between platelet count and various physiological markers.
url https://doi.org/10.1038/s42003-021-02642-9
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