A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models
While cannabis is perceived as a relatively safe drug by the public, accumulating clinical data suggest detrimental cardiovascular effects of cannabinoids. Cannabis has been legalized in several countries and jurisdictions recently. Experimental studies specifically targeting cannabinoids' effe...
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doaj-446a463b86ce4e1c806b0be3965441062020-11-24T22:13:39ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-05-01910.3389/fphys.2018.00622363348A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal ModelsJ. Sebastian Richter0J. Sebastian Richter1J. Sebastian Richter2Véronique Quenardelle3Véronique Quenardelle4Olivier Rouyer5Olivier Rouyer6Olivier Rouyer7Jean Sébastien Raul8Rémy Beaujeux9Rémy Beaujeux10Bernard Gény11Bernard Gény12Valérie Wolff13Valérie Wolff14Department of Interventional Neuroradiology, University Hospital of Strasbourg, Strasbourg, FranceInstitute of Image-Guided Surgery (IHU), Strasbourg, FranceEquipe d'Accueil 3072, University of Strasbourg, Strasbourg, FranceEquipe d'Accueil 3072, University of Strasbourg, Strasbourg, FranceStroke Unit, University Hospital, Strasbourg, FranceEquipe d'Accueil 3072, University of Strasbourg, Strasbourg, FranceStroke Unit, University Hospital, Strasbourg, FranceDepartment of Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, FranceInstitute of Legal Medicine, University of Strasbourg, Strasbourg, FranceDepartment of Interventional Neuroradiology, University Hospital of Strasbourg, Strasbourg, FranceInstitute of Image-Guided Surgery (IHU), Strasbourg, FranceEquipe d'Accueil 3072, University of Strasbourg, Strasbourg, FranceDepartment of Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, FranceEquipe d'Accueil 3072, University of Strasbourg, Strasbourg, FranceStroke Unit, University Hospital, Strasbourg, FranceWhile cannabis is perceived as a relatively safe drug by the public, accumulating clinical data suggest detrimental cardiovascular effects of cannabinoids. Cannabis has been legalized in several countries and jurisdictions recently. Experimental studies specifically targeting cannabinoids' effects on the cerebral vasculature are rare. There is evidence for transient vasoconstrictive effects of cannabinoids in the peripheral and cerebral vasculature in a complex interplay of vasodilation and vasoconstriction. Vasoreactivity to cannabinoids is dependent on the specific molecules, their metabolites and dose, baseline vascular tone, and vessel characteristics as well as experimental conditions and animal species. We systematically review the currently available literature of experimental results in in vivo and in vitro animal studies, examining cannabinoids' effects on circulation and reactive vasodilation or vasoconstriction, with a particular focus on the cerebral vascular bed.https://www.frontiersin.org/article/10.3389/fphys.2018.00622/fullcannabiscannabinoidsvasoreactivityvasoconstrictioncerebral vasospasmanimal models |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J. Sebastian Richter J. Sebastian Richter J. Sebastian Richter Véronique Quenardelle Véronique Quenardelle Olivier Rouyer Olivier Rouyer Olivier Rouyer Jean Sébastien Raul Rémy Beaujeux Rémy Beaujeux Bernard Gény Bernard Gény Valérie Wolff Valérie Wolff |
spellingShingle |
J. Sebastian Richter J. Sebastian Richter J. Sebastian Richter Véronique Quenardelle Véronique Quenardelle Olivier Rouyer Olivier Rouyer Olivier Rouyer Jean Sébastien Raul Rémy Beaujeux Rémy Beaujeux Bernard Gény Bernard Gény Valérie Wolff Valérie Wolff A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models Frontiers in Physiology cannabis cannabinoids vasoreactivity vasoconstriction cerebral vasospasm animal models |
author_facet |
J. Sebastian Richter J. Sebastian Richter J. Sebastian Richter Véronique Quenardelle Véronique Quenardelle Olivier Rouyer Olivier Rouyer Olivier Rouyer Jean Sébastien Raul Rémy Beaujeux Rémy Beaujeux Bernard Gény Bernard Gény Valérie Wolff Valérie Wolff |
author_sort |
J. Sebastian Richter |
title |
A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models |
title_short |
A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models |
title_full |
A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models |
title_fullStr |
A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models |
title_full_unstemmed |
A Systematic Review of the Complex Effects of Cannabinoids on Cerebral and Peripheral Circulation in Animal Models |
title_sort |
systematic review of the complex effects of cannabinoids on cerebral and peripheral circulation in animal models |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2018-05-01 |
description |
While cannabis is perceived as a relatively safe drug by the public, accumulating clinical data suggest detrimental cardiovascular effects of cannabinoids. Cannabis has been legalized in several countries and jurisdictions recently. Experimental studies specifically targeting cannabinoids' effects on the cerebral vasculature are rare. There is evidence for transient vasoconstrictive effects of cannabinoids in the peripheral and cerebral vasculature in a complex interplay of vasodilation and vasoconstriction. Vasoreactivity to cannabinoids is dependent on the specific molecules, their metabolites and dose, baseline vascular tone, and vessel characteristics as well as experimental conditions and animal species. We systematically review the currently available literature of experimental results in in vivo and in vitro animal studies, examining cannabinoids' effects on circulation and reactive vasodilation or vasoconstriction, with a particular focus on the cerebral vascular bed. |
topic |
cannabis cannabinoids vasoreactivity vasoconstriction cerebral vasospasm animal models |
url |
https://www.frontiersin.org/article/10.3389/fphys.2018.00622/full |
work_keys_str_mv |
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