Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder
Recent approaches have suggested that deep brain stimulation (DBS) for obsessive-compulsive disorder relies on distributed networks rather than local brain modulation. However, there is insufficient data on how DBS affects brain metabolism both locally and globally. We enrolled three patients with t...
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doaj-446d2653d7dc4ee5828b037a81ace12c2020-11-25T01:39:51ZengMDPI AGBrain Sciences2076-34252019-08-019922010.3390/brainsci9090220brainsci9090220Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive DisorderJuan Carlos Baldermann0Karl Peter Bohn1Jochen Hammes2Canan Beate Schüller3Veerle Visser-Vandewalle4Alexander Drzezga5Jens Kuhn6Department of Psychiatry and Psychotherapy, University of Cologne, Medical faculty, 50937 Cologne, GermanyDepartment of Nuclear Medicine, University of Cologne, Medical faculty, 50937 Cologne, GermanyDepartment of Nuclear Medicine, University of Cologne, Medical faculty, 50937 Cologne, GermanyDepartment of Psychiatry and Psychotherapy, University of Cologne, Medical faculty, 50937 Cologne, GermanyDepartment of Stereotactic and Functional Neurosurgery, University of Cologne, 50937 Cologne, GermanyDepartment of Nuclear Medicine, University of Cologne, Medical faculty, 50937 Cologne, GermanyDepartment of Psychiatry and Psychotherapy, University of Cologne, Medical faculty, 50937 Cologne, GermanyRecent approaches have suggested that deep brain stimulation (DBS) for obsessive-compulsive disorder relies on distributed networks rather than local brain modulation. However, there is insufficient data on how DBS affects brain metabolism both locally and globally. We enrolled three patients with treatment-refractory obsessive-compulsive disorder with ongoing DBS of the bilateral ventral capsule/ventral striatum. Patients underwent resting-state <sup>18</sup>F-fluorodeoxyglucose and positron emission tomography in both stimulation ON and OFF conditions. All subjects showed relative hypometabolism in prefronto-basal ganglia-thalamic networks compared to a healthy control cohort when stimulation was switched OFF. Switching the stimulation ON resulted in differential changes in brain metabolism. Locally, volumes of activated tissue at stimulation sites (<i>n</i> = 6) showed a significant increase in metabolism during DBS ON compared to DBS OFF (Mean difference 4.5% ± SD 2.8; <i>p</i> = 0.012). Globally, differential changes were observed across patients encompassing prefrontal increase in metabolism in ON vs. OFF condition. Bearing in mind limitations of the small sample size, we conclude that DBS of the ventral capsule/ventral striatum for obsessive-compulsive disorder increases brain metabolism locally. Across distributed global networks, DBS appears to exert differential effects, possibly depending on localization of stimulation sites and response to the intervention.https://www.mdpi.com/2076-3425/9/9/220Deep brain stimulationDBSObsessive-Compulsive DisorderOCDPositron emission tomography18F-fluorodeoxyglucoseFDG-PET |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan Carlos Baldermann Karl Peter Bohn Jochen Hammes Canan Beate Schüller Veerle Visser-Vandewalle Alexander Drzezga Jens Kuhn |
spellingShingle |
Juan Carlos Baldermann Karl Peter Bohn Jochen Hammes Canan Beate Schüller Veerle Visser-Vandewalle Alexander Drzezga Jens Kuhn Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder Brain Sciences Deep brain stimulation DBS Obsessive-Compulsive Disorder OCD Positron emission tomography 18F-fluorodeoxyglucose FDG-PET |
author_facet |
Juan Carlos Baldermann Karl Peter Bohn Jochen Hammes Canan Beate Schüller Veerle Visser-Vandewalle Alexander Drzezga Jens Kuhn |
author_sort |
Juan Carlos Baldermann |
title |
Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder |
title_short |
Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder |
title_full |
Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder |
title_fullStr |
Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder |
title_full_unstemmed |
Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder |
title_sort |
local and global changes in brain metabolism during deep brain stimulation for obsessive-compulsive disorder |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2019-08-01 |
description |
Recent approaches have suggested that deep brain stimulation (DBS) for obsessive-compulsive disorder relies on distributed networks rather than local brain modulation. However, there is insufficient data on how DBS affects brain metabolism both locally and globally. We enrolled three patients with treatment-refractory obsessive-compulsive disorder with ongoing DBS of the bilateral ventral capsule/ventral striatum. Patients underwent resting-state <sup>18</sup>F-fluorodeoxyglucose and positron emission tomography in both stimulation ON and OFF conditions. All subjects showed relative hypometabolism in prefronto-basal ganglia-thalamic networks compared to a healthy control cohort when stimulation was switched OFF. Switching the stimulation ON resulted in differential changes in brain metabolism. Locally, volumes of activated tissue at stimulation sites (<i>n</i> = 6) showed a significant increase in metabolism during DBS ON compared to DBS OFF (Mean difference 4.5% ± SD 2.8; <i>p</i> = 0.012). Globally, differential changes were observed across patients encompassing prefrontal increase in metabolism in ON vs. OFF condition. Bearing in mind limitations of the small sample size, we conclude that DBS of the ventral capsule/ventral striatum for obsessive-compulsive disorder increases brain metabolism locally. Across distributed global networks, DBS appears to exert differential effects, possibly depending on localization of stimulation sites and response to the intervention. |
topic |
Deep brain stimulation DBS Obsessive-Compulsive Disorder OCD Positron emission tomography 18F-fluorodeoxyglucose FDG-PET |
url |
https://www.mdpi.com/2076-3425/9/9/220 |
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