Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report
Stromal tumours occurring in areas other than the GastroIntestinal Tract (GIT) are known as Extra GastroIntestinal Stromal Tumours (EGISTs). They usually arise in the mesentery, omentum or retroperitoneum, while EGISTs which occur in the abdominal wall are very rare. Both gastrointestinal stromal...
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doaj-446fea13a0b5468dae3d7d2aa3e817142020-11-25T03:22:01ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-12-017122970297210.7860/JCDR/2013/7863.3812Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case ReportA. Sathish Selva Kumar0R. Padmini1G. Veena2N. Murugesan3Assistant Professor, Department of Pathology, Affiliated to ESIC-Medical College & PGIMSR, K.K.Nagar, Chennai-78, India.Senior Resident, Department of Pathology, Affiliated to ESIC-Medical College & PGIMSR, K.K.Nagar, Chennai-78, India.Senior Resident, Department of Pathology, Affiliated to ESIC-Medical College & PGIMSR, K.K.Nagar, Chennai-78, India.CMO/Senior Resident, Department of Surgery, Affiliated to ESIC-Medical College & PGIMSR, K.K.Nagar, Chennai-78, India.Stromal tumours occurring in areas other than the GastroIntestinal Tract (GIT) are known as Extra GastroIntestinal Stromal Tumours (EGISTs). They usually arise in the mesentery, omentum or retroperitoneum, while EGISTs which occur in the abdominal wall are very rare. Both gastrointestinal stromal tumours (GISTs) and EGISTs are histologically and immunophenotypically similar. We are reporting a case of EGIST, which occurred in the anterior abdominal wall in a twenty five-year-old female patient. The tumour was present in the right loin and imaging studies suggested that it was a desmoid tumour. It was surgically excised by doing an abdominal wall mesh repair. The histological examinations revealed a tumour with spindle cell morphology, with <2 mitoses per 50 High Power Field (HPF) and no necrosis, with tumour free margins. Immunohistochemistry was strongly positive for CD117 and Smooth Muscle Actin (SMA), while it was negative for β-catenin and S100. The patient is well post operatively and is on close follow up. EGISTs should be considered in the differential diagnosis of mesenchymal tumours which occur in the abdominal wall, inspite of their rarity, as the high risk patients may need Imatinib chemotherapy.https://jcdr.net/articles/PDF/3812/93-%207863_E(C)_F(H)_PF1(Ma_PSH)_PFA(H)_PF2(PP).pdfcd117β-cateninimatinib |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
A. Sathish Selva Kumar R. Padmini G. Veena N. Murugesan |
spellingShingle |
A. Sathish Selva Kumar R. Padmini G. Veena N. Murugesan Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report Journal of Clinical and Diagnostic Research cd117 β-catenin imatinib |
author_facet |
A. Sathish Selva Kumar R. Padmini G. Veena N. Murugesan |
author_sort |
A. Sathish Selva Kumar |
title |
Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report |
title_short |
Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report |
title_full |
Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report |
title_fullStr |
Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report |
title_full_unstemmed |
Extragastrointestinal Stromal Tumour of The Abdominal Wall - A Case Report |
title_sort |
extragastrointestinal stromal tumour of the abdominal wall - a case report |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2013-12-01 |
description |
Stromal tumours occurring in areas other than the GastroIntestinal Tract (GIT) are known as Extra GastroIntestinal Stromal Tumours
(EGISTs). They usually arise in the mesentery, omentum or retroperitoneum, while EGISTs which occur in the abdominal wall are very
rare. Both gastrointestinal stromal tumours (GISTs) and EGISTs are histologically and immunophenotypically similar. We are reporting a
case of EGIST, which occurred in the anterior abdominal wall in a twenty five-year-old female patient. The tumour was present in the right
loin and imaging studies suggested that it was a desmoid tumour. It was surgically excised by doing an abdominal wall mesh repair. The
histological examinations revealed a tumour with spindle cell morphology, with <2 mitoses per 50 High Power Field (HPF) and no necrosis,
with tumour free margins. Immunohistochemistry was strongly positive for CD117 and Smooth Muscle Actin (SMA), while it was negative
for β-catenin and S100. The patient is well post operatively and is on close follow up. EGISTs should be considered in the differential
diagnosis of mesenchymal tumours which occur in the abdominal wall, inspite of their rarity, as the high risk patients may need Imatinib
chemotherapy. |
topic |
cd117 β-catenin imatinib |
url |
https://jcdr.net/articles/PDF/3812/93-%207863_E(C)_F(H)_PF1(Ma_PSH)_PFA(H)_PF2(PP).pdf |
work_keys_str_mv |
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