Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules
Purpose The purpose of this study was to present the distribution of lesions among the six categories of the pathology reporting system for thyroid core-needle biopsy (CNB), along with the range of malignancy risk of each category based on different diagnostic criteria for benignity in a clinical co...
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doaj-4475ef6192484f5386f1b91f945364242020-11-25T01:21:30ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59192288-59432020-04-0139215916510.14366/usg.190561089Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodulesHye Min Son0Ji-hoon Kim1Soo Chin Kim2Roh-Eul Yoo3Jeong Mo Bae4Hyobin Seo5Dong Gyu Na6 Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea Department of Radiology, Seoul National University Hospital, Seoul, Korea Department of Pathology, Seoul National University Hospital, Seoul, Korea Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea Department of Radiology, Human Medical Imaging and Intervention Center, Seoul, KoreaPurpose The purpose of this study was to present the distribution of lesions among the six categories of the pathology reporting system for thyroid core-needle biopsy (CNB), along with the range of malignancy risk of each category based on different diagnostic criteria for benignity in a clinical cohort. Methods For 1,216 consecutive nodules (≥1 cm) of 1,125 patients who underwent CNB at two hospitals, the diagnostic results based on the six categories of thyroid CNB were analyzed. Patients were divided into three groups according to prior fine-needle aspiration (FNA) status: second-line CNB for nodules where prior FNA yielded nondiagnostic or unsatisfactory results (n=57), second-line CNB for nodules with prior FNA results of atypia/follicular lesion of undetermined significance (AUS/FLUS) (n=303), and first-line CNB (n=856). Results The proportion of nodules in each CNB category and the range of the malignancy rate for each category was as follows, in order from category I to VI: 1.8%, 23.1%-75.0%; 57.9%, 0.7%-16.7%; 16.0%, 13.2%-46.7%; 8.8%, 53.8%-56.8%; 2.0%, 100%; and 13.5%, 100%. First-line CNB was associated with a higher rate of conclusive diagnoses (category II, IV, or VI) (725 of 856, 84.7%) than second-line CNB with prior nondiagnostic or AUS/FLUS FNA results (241 of 360, 66.9%; P<0.001). Conclusion The overall distribution of nodules across the six categories of thyroid CNB and the ranges of malignancy risk for those categories were presented in a clinical cohort. First-line CNB tended to produce a higher rate of conclusive results than second-line CNB with prior inconclusive FNA results.http://www.e-ultrasonography.org/upload/usg-19056.pdfthyroidcore needle biopsymalignancy riskincidencepathology report system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hye Min Son Ji-hoon Kim Soo Chin Kim Roh-Eul Yoo Jeong Mo Bae Hyobin Seo Dong Gyu Na |
spellingShingle |
Hye Min Son Ji-hoon Kim Soo Chin Kim Roh-Eul Yoo Jeong Mo Bae Hyobin Seo Dong Gyu Na Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules Ultrasonography thyroid core needle biopsy malignancy risk incidence pathology report system |
author_facet |
Hye Min Son Ji-hoon Kim Soo Chin Kim Roh-Eul Yoo Jeong Mo Bae Hyobin Seo Dong Gyu Na |
author_sort |
Hye Min Son |
title |
Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules |
title_short |
Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules |
title_full |
Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules |
title_fullStr |
Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules |
title_full_unstemmed |
Distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules |
title_sort |
distribution and malignancy risk of six categories of the pathology reporting system for thyroid core-needle biopsy in 1,216 consecutive thyroid nodules |
publisher |
Korean Society of Ultrasound in Medicine |
series |
Ultrasonography |
issn |
2288-5919 2288-5943 |
publishDate |
2020-04-01 |
description |
Purpose The purpose of this study was to present the distribution of lesions among the six categories of the pathology reporting system for thyroid core-needle biopsy (CNB), along with the range of malignancy risk of each category based on different diagnostic criteria for benignity in a clinical cohort. Methods For 1,216 consecutive nodules (≥1 cm) of 1,125 patients who underwent CNB at two hospitals, the diagnostic results based on the six categories of thyroid CNB were analyzed. Patients were divided into three groups according to prior fine-needle aspiration (FNA) status: second-line CNB for nodules where prior FNA yielded nondiagnostic or unsatisfactory results (n=57), second-line CNB for nodules with prior FNA results of atypia/follicular lesion of undetermined significance (AUS/FLUS) (n=303), and first-line CNB (n=856). Results The proportion of nodules in each CNB category and the range of the malignancy rate for each category was as follows, in order from category I to VI: 1.8%, 23.1%-75.0%; 57.9%, 0.7%-16.7%; 16.0%, 13.2%-46.7%; 8.8%, 53.8%-56.8%; 2.0%, 100%; and 13.5%, 100%. First-line CNB was associated with a higher rate of conclusive diagnoses (category II, IV, or VI) (725 of 856, 84.7%) than second-line CNB with prior nondiagnostic or AUS/FLUS FNA results (241 of 360, 66.9%; P<0.001). Conclusion The overall distribution of nodules across the six categories of thyroid CNB and the ranges of malignancy risk for those categories were presented in a clinical cohort. First-line CNB tended to produce a higher rate of conclusive results than second-line CNB with prior inconclusive FNA results. |
topic |
thyroid core needle biopsy malignancy risk incidence pathology report system |
url |
http://www.e-ultrasonography.org/upload/usg-19056.pdf |
work_keys_str_mv |
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