Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. In HD, striking neuropathological changes occur in the striatum, including loss...

Full description

Bibliographic Details
Main Authors: Ryoma Morigaki, Satoshi Goto
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Brain Sciences
Subjects:
Huntington’s disease
huntingtin
striatum
medium spiny neuron
pathophysiology
striosome
matrix
Online Access:http://www.mdpi.com/2076-3425/7/6/63

Internet

http://www.mdpi.com/2076-3425/7/6/63

Similar Items