Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein. In HD, striking neuropathological changes occur in the striatum, including loss...
Main Authors: | Ryoma Morigaki, Satoshi Goto |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2017-06-01
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Series: | Brain Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/2076-3425/7/6/63 |
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