Zinc is a potent and specific inhibitor of IFN-λ3 signalling

Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.

Bibliographic Details
Main Authors:	Scott A. Read, Kate S. O’Connor, Vijay Suppiah, Chantelle L. E. Ahlenstiel, Stephanie Obeid, Kristina M. Cook, Anthony Cunningham, Mark W. Douglas, Philip J. Hogg, David Booth, Jacob George, Golo Ahlenstiel
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15245

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spelling	doaj-448cc0a156b540329808e92d9913726d2021-05-11T07:44:45ZengNature Publishing GroupNature Communications2041-17232017-05-018111510.1038/ncomms15245Zinc is a potent and specific inhibitor of IFN-λ3 signallingScott A. Read0Kate S. O’Connor1Vijay Suppiah2Chantelle L. E. Ahlenstiel3Stephanie Obeid4Kristina M. Cook5Anthony Cunningham6Mark W. Douglas7Philip J. Hogg8David Booth9Jacob George10Golo Ahlenstiel11Storr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalCentre for Immunology and Allergy Research, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalSchool of Pharmacy and Medical Science, University of South AustraliaThe Kirby Institute for Infection and Immunity in Society, University of New South WalesStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalThe Centenary InstituteCentre of Virus Research, Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalNational Health and Medical Research Council Clinical Trials Centre, University of SydneyCentre for Immunology and Allergy Research, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalStorr Liver Centre, The Westmead Institute for Medical Research, The University of Sydney and Westmead HospitalLambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.https://doi.org/10.1038/ncomms15245
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Scott A. Read Kate S. O’Connor Vijay Suppiah Chantelle L. E. Ahlenstiel Stephanie Obeid Kristina M. Cook Anthony Cunningham Mark W. Douglas Philip J. Hogg David Booth Jacob George Golo Ahlenstiel
spellingShingle	Scott A. Read Kate S. O’Connor Vijay Suppiah Chantelle L. E. Ahlenstiel Stephanie Obeid Kristina M. Cook Anthony Cunningham Mark W. Douglas Philip J. Hogg David Booth Jacob George Golo Ahlenstiel Zinc is a potent and specific inhibitor of IFN-λ3 signalling Nature Communications
author_facet	Scott A. Read Kate S. O’Connor Vijay Suppiah Chantelle L. E. Ahlenstiel Stephanie Obeid Kristina M. Cook Anthony Cunningham Mark W. Douglas Philip J. Hogg David Booth Jacob George Golo Ahlenstiel
author_sort	Scott A. Read
title	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_short	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_full	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_fullStr	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_full_unstemmed	Zinc is a potent and specific inhibitor of IFN-λ3 signalling
title_sort	zinc is a potent and specific inhibitor of ifn-λ3 signalling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.
url	https://doi.org/10.1038/ncomms15245
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Zinc is a potent and specific inhibitor of IFN-λ3 signalling

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