Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

Various biotin-modified liposomes incorporated with docetaxel (DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome (PDL), 0.5% (mol) biotin modified liposome (0.5BDL), 1% (mol) biotin m...

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Bibliographic Details
Main Authors: Chun Chu, Ping Xu, Haoyue Zhao, Qing Chen, Dawei Chen, Haiyang Hu, Xiuli Zhao, Mingxi Qiao
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Docetaxel
Liposomes
Biotin
Ligand density
Tumor targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300253

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