DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation
Abstract Background Renal masses are becoming an increasingly common finding on cross-sectional images. Characterization of the nature of the lesion either neoplastic or not, benign or malignant as well as further subtype characterization is becoming an important factor in determining management pla...
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doaj-448f1a2a8cc9416dbd3de4275325ef262021-08-15T11:31:30ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622021-08-0152111310.1186/s43055-021-00565-3DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlationMohamed Samir Shaaban0Viviane George Adly Ayad1Mohamed Sharafeldeen2Mona A. Salem3M. A. Atta4Adel A. Ramadan5Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria UniversityDepartment of Urology, Faculty of Medicine, Alexandria UniversityDepartment of Pathology, Faculty of Medicine, Alexandria UniversityDepartment of Urology, Faculty of Medicine, Alexandria UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Alexandria UniversityAbstract Background Renal masses are becoming an increasingly common finding on cross-sectional images. Characterization of the nature of the lesion either neoplastic or not, benign or malignant as well as further subtype characterization is becoming an important factor in determining management plan. The purpose of our study with to assess the sensitivity and specificity of both ADC mean value and ADC ratio in such characterization along with the calculation of different cutoff values to differentiate between different varieties, using pathological data as the main gold standard for diagnosis. Results Our study included 50 patients with a total of 72 masses. A final diagnosis was reached in 69 masses by pathological examination and three masses had clinical and laboratory signs of infection. We had a total of 49 malignant lesions (68%) and 23 benign lesions (32%). The ADC value of ccRCC (1.4 × 10−3 mm2/s) was significantly higher than all other renal masses. A cutoff ADC value of > 1.1 and a cutoff ADC ratio of > 0.56 can be used to differentiate between clear cell renal cell carcinoma and other lesions and an ADC value of < 0.8 and an ADC ratio of ≤ 0.56 to differentiate papillary renal cell carcinoma from other masses. There was no statistically significant ADC value to differentiate between benign and malignant lesions but a statistically significant ADC ratio (> 0.52) was reached. Conclusion ADC value and ADC ratio can be used as an adjunct tool in the characterization of different renal masses, with ADC ratio having a higher sensitivity, which can affect the prognosis and management of the patient.https://doi.org/10.1186/s43055-021-00565-3KidneyNeoplasmDiffusion-weighted imagingADC valueADC ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed Samir Shaaban Viviane George Adly Ayad Mohamed Sharafeldeen Mona A. Salem M. A. Atta Adel A. Ramadan |
spellingShingle |
Mohamed Samir Shaaban Viviane George Adly Ayad Mohamed Sharafeldeen Mona A. Salem M. A. Atta Adel A. Ramadan DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation The Egyptian Journal of Radiology and Nuclear Medicine Kidney Neoplasm Diffusion-weighted imaging ADC value ADC ratio |
author_facet |
Mohamed Samir Shaaban Viviane George Adly Ayad Mohamed Sharafeldeen Mona A. Salem M. A. Atta Adel A. Ramadan |
author_sort |
Mohamed Samir Shaaban |
title |
DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation |
title_short |
DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation |
title_full |
DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation |
title_fullStr |
DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation |
title_full_unstemmed |
DWI and ADC value versus ADC ratio in the characterization of solid renal masses: radiologic-pathologic correlation |
title_sort |
dwi and adc value versus adc ratio in the characterization of solid renal masses: radiologic-pathologic correlation |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Radiology and Nuclear Medicine |
issn |
2090-4762 |
publishDate |
2021-08-01 |
description |
Abstract Background Renal masses are becoming an increasingly common finding on cross-sectional images. Characterization of the nature of the lesion either neoplastic or not, benign or malignant as well as further subtype characterization is becoming an important factor in determining management plan. The purpose of our study with to assess the sensitivity and specificity of both ADC mean value and ADC ratio in such characterization along with the calculation of different cutoff values to differentiate between different varieties, using pathological data as the main gold standard for diagnosis. Results Our study included 50 patients with a total of 72 masses. A final diagnosis was reached in 69 masses by pathological examination and three masses had clinical and laboratory signs of infection. We had a total of 49 malignant lesions (68%) and 23 benign lesions (32%). The ADC value of ccRCC (1.4 × 10−3 mm2/s) was significantly higher than all other renal masses. A cutoff ADC value of > 1.1 and a cutoff ADC ratio of > 0.56 can be used to differentiate between clear cell renal cell carcinoma and other lesions and an ADC value of < 0.8 and an ADC ratio of ≤ 0.56 to differentiate papillary renal cell carcinoma from other masses. There was no statistically significant ADC value to differentiate between benign and malignant lesions but a statistically significant ADC ratio (> 0.52) was reached. Conclusion ADC value and ADC ratio can be used as an adjunct tool in the characterization of different renal masses, with ADC ratio having a higher sensitivity, which can affect the prognosis and management of the patient. |
topic |
Kidney Neoplasm Diffusion-weighted imaging ADC value ADC ratio |
url |
https://doi.org/10.1186/s43055-021-00565-3 |
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