The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy
Abstract Background There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck...
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doaj-44950a0abf4944f88225bff29e2f7b4f2020-11-25T04:08:02ZengBMCRadiation Oncology1748-717X2020-11-0115111210.1186/s13014-020-01702-4The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapyDaniela Delago0Olivia Knittelfelder1Gabriele Jakse2Katarzyna Lukasiak3Sabine Reinisch4Wilfried Renner5Heidi Stranzl-Lawatsch6Richard Partl7Tanja Langsenlehner8Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazDepartment of Otorhinolaryngology, Comprehensive Cancer Center, Medical University of GrazClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of GrazDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of GrazAbstract Background There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck squamous cell cancer (HNSCC) is currently discussed controversially. The present study was performed to analyze and further elucidate the prognostic significance of the MPV in HNSCC. Methods A total of 319 oropharyngeal squamous cell cancer (OPSCC) patients treated with radiotherapy at a tertiary academic center were enrolled in the present study. Kaplan–Meier method as well as uni- and multivariate Cox proportional hazards were used to evaluate the impact of MPV on cancer-specific survival (CSS), locoregional control (LC) and recurrence-free survival (RFS). Results The median MPV was 10.30 fL (mean 10.26 ± 1.17fL). Univariate analyses showed a significant association of the MPV with CSS (HR 0.85, 95% CI 0.74–0.98, p = 0.025), LC (HR 0.86, 95% CI 0.74–0.99, p = 0.034) and RFS (HR 0.87, 95% CI 0.76–0.996; p = 0.043). In multivariate analysis, the MPV remained an independent prognostic factor for CSS (HR 0.77, 95% CI 0.63–0.93, p = 0.008), LC (HR 0.80, 95% CI 0.65–0.98, p = 0.030), and RFS (HR 0.83, 95% CI 0.685–0.999, p = 0.049). Conclusions Our findings indicate that the MPV is a prognostic marker in OPSCC patients and may contribute to future individual risk assessment.http://link.springer.com/article/10.1186/s13014-020-01702-4Oropharyngeal cancerBiomarkerMean platelet volumePrognostic factorOutcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniela Delago Olivia Knittelfelder Gabriele Jakse Katarzyna Lukasiak Sabine Reinisch Wilfried Renner Heidi Stranzl-Lawatsch Richard Partl Tanja Langsenlehner |
spellingShingle |
Daniela Delago Olivia Knittelfelder Gabriele Jakse Katarzyna Lukasiak Sabine Reinisch Wilfried Renner Heidi Stranzl-Lawatsch Richard Partl Tanja Langsenlehner The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy Radiation Oncology Oropharyngeal cancer Biomarker Mean platelet volume Prognostic factor Outcome |
author_facet |
Daniela Delago Olivia Knittelfelder Gabriele Jakse Katarzyna Lukasiak Sabine Reinisch Wilfried Renner Heidi Stranzl-Lawatsch Richard Partl Tanja Langsenlehner |
author_sort |
Daniela Delago |
title |
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy |
title_short |
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy |
title_full |
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy |
title_fullStr |
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy |
title_full_unstemmed |
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy |
title_sort |
decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy |
publisher |
BMC |
series |
Radiation Oncology |
issn |
1748-717X |
publishDate |
2020-11-01 |
description |
Abstract Background There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck squamous cell cancer (HNSCC) is currently discussed controversially. The present study was performed to analyze and further elucidate the prognostic significance of the MPV in HNSCC. Methods A total of 319 oropharyngeal squamous cell cancer (OPSCC) patients treated with radiotherapy at a tertiary academic center were enrolled in the present study. Kaplan–Meier method as well as uni- and multivariate Cox proportional hazards were used to evaluate the impact of MPV on cancer-specific survival (CSS), locoregional control (LC) and recurrence-free survival (RFS). Results The median MPV was 10.30 fL (mean 10.26 ± 1.17fL). Univariate analyses showed a significant association of the MPV with CSS (HR 0.85, 95% CI 0.74–0.98, p = 0.025), LC (HR 0.86, 95% CI 0.74–0.99, p = 0.034) and RFS (HR 0.87, 95% CI 0.76–0.996; p = 0.043). In multivariate analysis, the MPV remained an independent prognostic factor for CSS (HR 0.77, 95% CI 0.63–0.93, p = 0.008), LC (HR 0.80, 95% CI 0.65–0.98, p = 0.030), and RFS (HR 0.83, 95% CI 0.685–0.999, p = 0.049). Conclusions Our findings indicate that the MPV is a prognostic marker in OPSCC patients and may contribute to future individual risk assessment. |
topic |
Oropharyngeal cancer Biomarker Mean platelet volume Prognostic factor Outcome |
url |
http://link.springer.com/article/10.1186/s13014-020-01702-4 |
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