Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling

Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling

Abstract Background Polo-like kinase 3 (PLK3) has been documented as a tumor suppressor in several types of malignancies. However, the role of PLK3 in colorectal cancer (CRC) progression and glucose metabolism remains to be known. Methods The expression of PLK3 in CRC tissues was determined by immun...

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Bibliographic Details
Main Authors: Baochi Ou, Hongze Sun, Jingkun Zhao, Zhuoqing Xu, Yuan Liu, Hao Feng, Zhihai Peng
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
PLK3
Glucose metabolism
HSP90
STAT3
HK2
Online Access:http://link.springer.com/article/10.1186/s13046-019-1418-2

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http://link.springer.com/article/10.1186/s13046-019-1418-2

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