Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

The membrane-bound transcription factor ATF6α plays a cytoprotective role in the unfolded protein response (UPR), required for cells to survive ER stress. Activation of ATF6α promotes cell survival in cancer models. We used cell-based screens to discover and develop Ceapins, a class of pyrazole amid...

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Bibliographic Details
Main Authors:	Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2016-07-01
Series:	eLife
Subjects:	endoplasmic reticulum unfolded protein response small molecule screening ATF6-alpha site-1-protease ER to Golgi trafficking
Online Access:	https://elifesciences.org/articles/11878

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