Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting
Current tissue engineering strategies lack materials that promote angiogenesis. Here the authors develop a microfluidic in vitro model in which chemokine-guided endothelial cell sprouting into a tunable hydrogel is followed by the formation of perfusable lumens to determine the material properties t...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-23644-5 |