Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients
Abstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acqui...
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2021-02-01
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Series: | npj Schizophrenia |
Online Access: | https://doi.org/10.1038/s41537-021-00146-3 |
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doaj-44b3c2c2ed4448aaa08e7447ae69e7ae2021-03-11T11:47:52ZengNature Publishing Groupnpj Schizophrenia2334-265X2021-02-01711910.1038/s41537-021-00146-3Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patientsRodolfo Solís-Vivanco0Alejandra Mondragón-Maya1Francisco Reyes-Madrigal2Camilo de la Fuente-Sandoval3Laboratory of Neuropsychology, Instituto Nacional de Neurología y NeurocirugíaFaculty of Higher Studies Iztacala, Universidad Nacional Autónoma de MéxicoLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y NeurocirugíaLaboratory of Experimental Psychiatry, Instituto Nacional de Neurología y NeurocirugíaAbstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms.https://doi.org/10.1038/s41537-021-00146-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rodolfo Solís-Vivanco Alejandra Mondragón-Maya Francisco Reyes-Madrigal Camilo de la Fuente-Sandoval |
spellingShingle |
Rodolfo Solís-Vivanco Alejandra Mondragón-Maya Francisco Reyes-Madrigal Camilo de la Fuente-Sandoval Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients npj Schizophrenia |
author_facet |
Rodolfo Solís-Vivanco Alejandra Mondragón-Maya Francisco Reyes-Madrigal Camilo de la Fuente-Sandoval |
author_sort |
Rodolfo Solís-Vivanco |
title |
Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients |
title_short |
Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients |
title_full |
Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients |
title_fullStr |
Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients |
title_full_unstemmed |
Impairment of novelty-related theta oscillations and P3a in never medicated first-episode psychosis patients |
title_sort |
impairment of novelty-related theta oscillations and p3a in never medicated first-episode psychosis patients |
publisher |
Nature Publishing Group |
series |
npj Schizophrenia |
issn |
2334-265X |
publishDate |
2021-02-01 |
description |
Abstract We explored the neurophysiological activity underlying auditory novelty detection in antipsychotic-naive patients with a first episode of psychosis (FEP). Fifteen patients with a non-affective FEP and 13 healthy controls underwent an active involuntary attention task along with an EEG acquisition. Time-frequency representations of power, phase locking, and fronto-parietal connectivity were calculated. The P3a event-related potential was extracted as well. Compared to controls, the FEP group showed reduced theta phase-locking and fronto-parietal connectivity evoked by deviant stimuli. Also, the P3a amplitude was significantly reduced. Moreover, reduced theta connectivity was associated with more severe negative symptoms within the FEP group. Reduced activity (phase-locking and connectivity) of novelty-related theta oscillations, along with P3a reduction, may represent a failure to synchronize large-scale neural populations closely related to fronto-parietal attentional networks, and might be explored as a potential biomarker of disease severity in patients with emerging psychosis, given its association with negative symptoms. |
url |
https://doi.org/10.1038/s41537-021-00146-3 |
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