The PI3Kδ Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL

The PI3Kδ Inhibitor Idelalisib Inhibits Homing in an in Vitro and in Vivo Model of B ALL

The quest continues for targeted therapies to reduce the morbidity of chemotherapy and to improve the response of resistant leukemia. Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stromal cells triggers intracellular signals that promote cell-adhesion-mediated drug resistance (...

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Bibliographic Details
Main Authors: Etai Adam, Hye Na Kim, Eun Ji Gang, Caitlin Schnair, Solomon Lee, Solah Lee, Sajad Khazal, Osanna Kosoyan, Marina Konopleva, Chintan Parekh, Deepa Bhojwani, Alan S. Wayne, Hisham Abdel-Azim, Nora Heisterkamp, Yong-Mi Kim
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Cancers
Subjects:
ALL
PI3K
drug resistance
CAM-DR
idelalisib
migration
mouse model
leukemia
Online Access:https://www.mdpi.com/2072-6694/9/9/121

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https://www.mdpi.com/2072-6694/9/9/121

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