Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa
The aim of this study was to examine differences in brain neural activation in response to monosodium glutamate (MSG), the representative component of umami, between patients with bulimia nervosa (BN) and healthy women (HW) controls. We analyzed brain activity after ingestion of an MSG solution usin...
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doaj-44bba93579184eec9df2d440837b79e12020-11-24T22:51:34ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-09-01810.3389/fpsyt.2017.00172286349Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia NervosaRikukage Setsu0Yoshiyuki Hirano1Miki Tokunaga2Toru Takahashi3Noriko Numata4Koji Matsumoto5Yoshitada Masuda6Daisuke Matsuzawa7Daisuke Matsuzawa8Masaomi Iyo9Eiji Shimizu10Eiji Shimizu11Michiko Nakazato12Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, JapanResearch Center for Child Mental Development, Chiba University, Chiba, JapanSchool of Nutrition and Dietetics, Kanagawa University of Human Services, Yokosuka, JapanDepartment of Nutrition and Health Sciences, Fukuoka Women’s University, Fukuoka, JapanResearch Center for Child Mental Development, Chiba University, Chiba, JapanDepartment of Radiology, Chiba University Hospital, Chiba, JapanDepartment of Radiology, Chiba University Hospital, Chiba, JapanDepartment of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, JapanResearch Center for Child Mental Development, Chiba University, Chiba, JapanDepartment of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, JapanDepartment of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, JapanResearch Center for Child Mental Development, Chiba University, Chiba, JapanDepartment of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, JapanThe aim of this study was to examine differences in brain neural activation in response to monosodium glutamate (MSG), the representative component of umami, between patients with bulimia nervosa (BN) and healthy women (HW) controls. We analyzed brain activity after ingestion of an MSG solution using functional magnetic resonance imaging (fMRI) in a group of women with BN (n = 18) and a group of HW participants (n = 18). Both groups also provided a subjective assessment of the MSG solution via a numerical rating scale. The BN group subjectively rated the MSG solution lower in pleasantness and liking than the control group, although no difference in subjective intensity was noted. The fMRI results demonstrated greater activation of the right insula in the BN group versus the control group. Compared with the HW controls, the BN patients demonstrated both altered taste perception-related brain activity and more negative hedonic scores in response to MSG stimuli. Different hedonic evaluation, expressed as the relative low pleasing taste of umami tastant and associated with altered insula function, may explain disturbed eating behaviors, including the imbalance in food choices, in BN patients.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00172/fulleating disordersbulimia nervosaumamiglutamatefunctional magnetic resonance imagingneuroimaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rikukage Setsu Yoshiyuki Hirano Miki Tokunaga Toru Takahashi Noriko Numata Koji Matsumoto Yoshitada Masuda Daisuke Matsuzawa Daisuke Matsuzawa Masaomi Iyo Eiji Shimizu Eiji Shimizu Michiko Nakazato |
spellingShingle |
Rikukage Setsu Yoshiyuki Hirano Miki Tokunaga Toru Takahashi Noriko Numata Koji Matsumoto Yoshitada Masuda Daisuke Matsuzawa Daisuke Matsuzawa Masaomi Iyo Eiji Shimizu Eiji Shimizu Michiko Nakazato Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa Frontiers in Psychiatry eating disorders bulimia nervosa umami glutamate functional magnetic resonance imaging neuroimaging |
author_facet |
Rikukage Setsu Yoshiyuki Hirano Miki Tokunaga Toru Takahashi Noriko Numata Koji Matsumoto Yoshitada Masuda Daisuke Matsuzawa Daisuke Matsuzawa Masaomi Iyo Eiji Shimizu Eiji Shimizu Michiko Nakazato |
author_sort |
Rikukage Setsu |
title |
Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa |
title_short |
Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa |
title_full |
Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa |
title_fullStr |
Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa |
title_full_unstemmed |
Increased Subjective Distaste and Altered Insula Activity to Umami Tastant in Patients with Bulimia Nervosa |
title_sort |
increased subjective distaste and altered insula activity to umami tastant in patients with bulimia nervosa |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2017-09-01 |
description |
The aim of this study was to examine differences in brain neural activation in response to monosodium glutamate (MSG), the representative component of umami, between patients with bulimia nervosa (BN) and healthy women (HW) controls. We analyzed brain activity after ingestion of an MSG solution using functional magnetic resonance imaging (fMRI) in a group of women with BN (n = 18) and a group of HW participants (n = 18). Both groups also provided a subjective assessment of the MSG solution via a numerical rating scale. The BN group subjectively rated the MSG solution lower in pleasantness and liking than the control group, although no difference in subjective intensity was noted. The fMRI results demonstrated greater activation of the right insula in the BN group versus the control group. Compared with the HW controls, the BN patients demonstrated both altered taste perception-related brain activity and more negative hedonic scores in response to MSG stimuli. Different hedonic evaluation, expressed as the relative low pleasing taste of umami tastant and associated with altered insula function, may explain disturbed eating behaviors, including the imbalance in food choices, in BN patients. |
topic |
eating disorders bulimia nervosa umami glutamate functional magnetic resonance imaging neuroimaging |
url |
http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00172/full |
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