Mass spectrometry imaging and LC/MS reveal decreased cerebellar phosphoinositides in Niemann-Pick type C1-null mice[S]
Niemann-Pick disease type C1 (NPC1) is a lipid storage disorder in which cholesterol and glycosphingolipids accumulate in late endosomal/lysosomal compartments because of mutations in the NPC1 gene. A hallmark of NPC1 is progressive neurodegeneration of the cerebellum as well as visceral organ damag...
Main Authors: | Koralege C. Pathmasiri, Melissa R. Pergande, Fernando Tobias, Rima Rebiai, Avia Rosenhouse-Dantsker, Ernesto R. Bongarzone, Stephanie M. Cologna |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-07-01
|
Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520435795 |
Similar Items
-
Phosphoinositide Phase Behavior in Complex Lipid Monolayer Systems
by: King, Katrice
Published: (2016) -
Biochemistry and structure of phosphoinositide phosphatases
by: Young Yil Bahk, et al.
Published: (2013-01-01) -
Signaling roles of phosphoinositides in the retina
by: Raju V.S. Rajala
Published: (2021-01-01) -
Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease
by: Sandra Torres, et al.
Published: (2017-11-01) -
Phosphoinositides in the kidney
by: Leopoldo Staiano, et al.
Published: (2019-02-01)