Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study
Background: Psychosocial stressors, such as perceived discrimination and depressive symptoms, may shorten telomeres and exacerbate aging-related illnesses. Methods: Participants from the Jackson Heart Study at visit 1 (2000–2004) with LTL data and Center for Epidemiological Studies-Depression (CES-D...
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doaj-44c457cff3b74521b5d4f286f686788c2021-06-01T01:24:50ZengMDPI AGHealthcare2227-90322021-05-01963963910.3390/healthcare9060639Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart StudyLáShauntá M. Glover0Crystal W. Cené1Alexander Reiner2Samson Gebreab3David R. Williams4Kari E. North5Mario Sims6Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Epidemiology, University of Washington, Seattle, WA 98195, USANational Institutes of Health, Bethesda, MD 20892, USADepartment of Social and Behavioral Sciences, T.H. Chan School of Public Health, Harvard University, Boston, MA 02138, USADepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USABackground: Psychosocial stressors, such as perceived discrimination and depressive symptoms, may shorten telomeres and exacerbate aging-related illnesses. Methods: Participants from the Jackson Heart Study at visit 1 (2000–2004) with LTL data and Center for Epidemiological Studies-Depression (CES-D) scores (<i>n</i> = 580 men, <i>n</i> = 910 women) were utilized. The dimensions of discrimination scores (everyday, lifetime, burden of lifetime, and stress from lifetime discrimination) were standardized and categorized as low, moderate, and high. Coping responses to everyday and lifetime discrimination were categorized as passive and active coping. Multivariable linear regression analyses were performed to estimate the mean difference (standard errors-SEs) in LTL by dimensions of discrimination and coping responses stratified by CES-D scores < 16 (low) and ≥ 16 (high) and sex. Covariates were age, education, waist circumference, smoking and CVD status. Results: Neither everyday nor lifetime discrimination was associated with mean differences in LTL for men or women by levels of depressive symptoms. Burden of lifetime discrimination was marginally associated with LTL among women who reported low depressive symptoms after full adjustment (b = 0.11, SE = 0.06, <i>p</i> = 0.08). Passive coping with lifetime discrimination was associated with longer LTL among men who reported low depressive symptoms after full adjustment (b = 0.18, SE = 0.09, <i>p</i> < 0.05); and active coping with lifetime discrimination was associated with longer LTL among men who reported high depressive symptoms after full adjustment (b = 1.18, SE = 0.35, <i>p</i> < 0.05). Conclusions: The intersection of perceived discrimination and depressive symptomatology may be related to LTL, and the effects may vary by sex.https://www.mdpi.com/2227-9032/9/6/639leukocyte telomere lengthdiscriminationdepressive symptomsAfrican American adults |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
LáShauntá M. Glover Crystal W. Cené Alexander Reiner Samson Gebreab David R. Williams Kari E. North Mario Sims |
spellingShingle |
LáShauntá M. Glover Crystal W. Cené Alexander Reiner Samson Gebreab David R. Williams Kari E. North Mario Sims Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study Healthcare leukocyte telomere length discrimination depressive symptoms African American adults |
author_facet |
LáShauntá M. Glover Crystal W. Cené Alexander Reiner Samson Gebreab David R. Williams Kari E. North Mario Sims |
author_sort |
LáShauntá M. Glover |
title |
Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study |
title_short |
Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study |
title_full |
Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study |
title_fullStr |
Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study |
title_full_unstemmed |
Discrimination and Leukocyte Telomere Length by Depressive Symptomatology: The Jackson Heart Study |
title_sort |
discrimination and leukocyte telomere length by depressive symptomatology: the jackson heart study |
publisher |
MDPI AG |
series |
Healthcare |
issn |
2227-9032 |
publishDate |
2021-05-01 |
description |
Background: Psychosocial stressors, such as perceived discrimination and depressive symptoms, may shorten telomeres and exacerbate aging-related illnesses. Methods: Participants from the Jackson Heart Study at visit 1 (2000–2004) with LTL data and Center for Epidemiological Studies-Depression (CES-D) scores (<i>n</i> = 580 men, <i>n</i> = 910 women) were utilized. The dimensions of discrimination scores (everyday, lifetime, burden of lifetime, and stress from lifetime discrimination) were standardized and categorized as low, moderate, and high. Coping responses to everyday and lifetime discrimination were categorized as passive and active coping. Multivariable linear regression analyses were performed to estimate the mean difference (standard errors-SEs) in LTL by dimensions of discrimination and coping responses stratified by CES-D scores < 16 (low) and ≥ 16 (high) and sex. Covariates were age, education, waist circumference, smoking and CVD status. Results: Neither everyday nor lifetime discrimination was associated with mean differences in LTL for men or women by levels of depressive symptoms. Burden of lifetime discrimination was marginally associated with LTL among women who reported low depressive symptoms after full adjustment (b = 0.11, SE = 0.06, <i>p</i> = 0.08). Passive coping with lifetime discrimination was associated with longer LTL among men who reported low depressive symptoms after full adjustment (b = 0.18, SE = 0.09, <i>p</i> < 0.05); and active coping with lifetime discrimination was associated with longer LTL among men who reported high depressive symptoms after full adjustment (b = 1.18, SE = 0.35, <i>p</i> < 0.05). Conclusions: The intersection of perceived discrimination and depressive symptomatology may be related to LTL, and the effects may vary by sex. |
topic |
leukocyte telomere length discrimination depressive symptoms African American adults |
url |
https://www.mdpi.com/2227-9032/9/6/639 |
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