Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function

Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function

TSPO is mainly expressed in the mitochondrial outer membrane of microglia in the central nervous system, and its expression is greatly increased when microglia are activated. However, the role and mechanism of this protein in microglial activation is not well characterized. In this study, we investi...

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Bibliographic Details
Main Authors: Rumeng Yao, Ruiyuan Pan, Chao Shang, Xiaoheng Li, Jinbo Cheng, Jiangping Xu, Yunfeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
TSPO
microglia
neuroinflammation
phagocytosis
mitochondrial
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00986/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00986/full

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