Therapeutic effects of blood purification in treatment of fulminant hepatic failure
OBJECTIVES: To evaluate the clinical effects of blood purification for treating fulminant hepatic failure (FHF). METHODS: Thirty-three severe FHF patients with hepatic encephalopathy (HE) above grade III were subjected to a combined blood purification treatment in addition to the comprehensive liver...
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doaj-44de322f8fc74db7b28257eeb40a47362020-11-25T03:46:07ZengElsevierBrazilian Journal of Infectious Diseases1678-439117442743010.1016/j.bjid.2012.11.008S1413-86702013000400007Therapeutic effects of blood purification in treatment of fulminant hepatic failureYunchuan Pu0Daokun Yang1Yanqun Mao2Ying Zhang3Kaihong Chen4Wuxi No. 5 People's HospitalXinxiang Medical UniversityWuxi No. 5 People's HospitalWuxi No. 5 People's HospitalWuxi No. 5 People's HospitalOBJECTIVES: To evaluate the clinical effects of blood purification for treating fulminant hepatic failure (FHF). METHODS: Thirty-three severe FHF patients with hepatic encephalopathy (HE) above grade III were subjected to a combined blood purification treatment in addition to the comprehensive liver protection therapy. Patients underwent continuous hemofiltration on a daily basis during the daytime followed by sequential treatment with plasma exchange or hemodialysis every 2-3 days. The therapeutic effects of this treatment were evaluated. RESULTS: After treatment with blood purification, restoration of consciousness (those who abandoned the treatment without restoration of consciousness were excluded) was achieved in 6 of 8 cases (75%) in acute liver failure (ALF) group, 3 of 3 cases (100%) in subacute liver failure (SALF) group, and 9 of 14 cases (64.29%) in acute/subacute on chronic liver failure (A/SCLF) group. Of all cases, 11 patients restored consciousness after 7 days in a coma. The rate of long-term survival (those who abandoned the treatment were excluded) was 3/7 (42.86%) for ALF group, 2/2 (100%) for SALF group, and 1/11 (9.09%) for A/SCLF group. The levels of hemoglobin and platelet in peripheral blood were significantly reduced after blood purification. CONCLUSIONS: Treatment of FHF patients with daily continuous hemofiltration during the daytime is effective in treating HE and in improving health status in the early stages of the disease. Long-term prognosis also benefits from this treatment. The rate of consciousness recovery and long-term survival is highest in SALF group followed by ALF group. This treatment is less effective in A/SCLF patients. It should be noted that blood purification procedure may cause damage to blood cells.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400007&lng=en&tlng=enLiver failureHepatic encephalopathyBlood purificationTherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunchuan Pu Daokun Yang Yanqun Mao Ying Zhang Kaihong Chen |
spellingShingle |
Yunchuan Pu Daokun Yang Yanqun Mao Ying Zhang Kaihong Chen Therapeutic effects of blood purification in treatment of fulminant hepatic failure Brazilian Journal of Infectious Diseases Liver failure Hepatic encephalopathy Blood purification Therapy |
author_facet |
Yunchuan Pu Daokun Yang Yanqun Mao Ying Zhang Kaihong Chen |
author_sort |
Yunchuan Pu |
title |
Therapeutic effects of blood purification in treatment of fulminant hepatic failure |
title_short |
Therapeutic effects of blood purification in treatment of fulminant hepatic failure |
title_full |
Therapeutic effects of blood purification in treatment of fulminant hepatic failure |
title_fullStr |
Therapeutic effects of blood purification in treatment of fulminant hepatic failure |
title_full_unstemmed |
Therapeutic effects of blood purification in treatment of fulminant hepatic failure |
title_sort |
therapeutic effects of blood purification in treatment of fulminant hepatic failure |
publisher |
Elsevier |
series |
Brazilian Journal of Infectious Diseases |
issn |
1678-4391 |
description |
OBJECTIVES: To evaluate the clinical effects of blood purification for treating fulminant hepatic failure (FHF). METHODS: Thirty-three severe FHF patients with hepatic encephalopathy (HE) above grade III were subjected to a combined blood purification treatment in addition to the comprehensive liver protection therapy. Patients underwent continuous hemofiltration on a daily basis during the daytime followed by sequential treatment with plasma exchange or hemodialysis every 2-3 days. The therapeutic effects of this treatment were evaluated. RESULTS: After treatment with blood purification, restoration of consciousness (those who abandoned the treatment without restoration of consciousness were excluded) was achieved in 6 of 8 cases (75%) in acute liver failure (ALF) group, 3 of 3 cases (100%) in subacute liver failure (SALF) group, and 9 of 14 cases (64.29%) in acute/subacute on chronic liver failure (A/SCLF) group. Of all cases, 11 patients restored consciousness after 7 days in a coma. The rate of long-term survival (those who abandoned the treatment were excluded) was 3/7 (42.86%) for ALF group, 2/2 (100%) for SALF group, and 1/11 (9.09%) for A/SCLF group. The levels of hemoglobin and platelet in peripheral blood were significantly reduced after blood purification. CONCLUSIONS: Treatment of FHF patients with daily continuous hemofiltration during the daytime is effective in treating HE and in improving health status in the early stages of the disease. Long-term prognosis also benefits from this treatment. The rate of consciousness recovery and long-term survival is highest in SALF group followed by ALF group. This treatment is less effective in A/SCLF patients. It should be noted that blood purification procedure may cause damage to blood cells. |
topic |
Liver failure Hepatic encephalopathy Blood purification Therapy |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400007&lng=en&tlng=en |
work_keys_str_mv |
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