Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil
Hepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From...
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doaj-44f0900dc1c64ec08b0366bd7932d00f2020-11-25T01:02:09ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.1678-8060010.1590/0074-02760160256S0074-02762016005020103Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central BrazilNara Rubia de FreitasEdna Braz Rocha de SantanaÁgabo Macedo da Costa e SilvaSueli Meira da SilvaSheila Araújo TelesNoemi Rovaris GardinaliMarcelo Alves PintoRegina Maria Bringel MartinsHepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From April 2012 to October 2014, a cross-sectional study was conducted among 379 patients with acute non-A, non-B, non-C hepatitis in the City of Goiania, Central Brazil. Serum samples of all patients were tested for serological markers of HEV infection (anti-HEV IgM and IgG) by ELISA. Positive samples were confirmed using immunoblot test. Anti-HEV IgM and IgG positive samples were tested for HEV RNA. Of the 379 serum samples, one (0.3%) and 20 (5.3%) were positive for anti-HEV IgM and IgG, respectively. HEV RNA was not found in any sample positive for IgM and/or IgG anti-HEV. After multivariate analysis, low education level was independently associated with HEV seropositivity (p = 0.005), as well as living in rural area, with a borderline p-value (p = 0.056). In conclusion, HEV may be responsible for sporadic self-limited cases of acute hepatitis in Central Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005020103&lng=en&tlng=enHepatitis E virusHEVepidemiologynon-A, non-B, non-C hepatitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nara Rubia de Freitas Edna Braz Rocha de Santana Ágabo Macedo da Costa e Silva Sueli Meira da Silva Sheila Araújo Teles Noemi Rovaris Gardinali Marcelo Alves Pinto Regina Maria Bringel Martins |
spellingShingle |
Nara Rubia de Freitas Edna Braz Rocha de Santana Ágabo Macedo da Costa e Silva Sueli Meira da Silva Sheila Araújo Teles Noemi Rovaris Gardinali Marcelo Alves Pinto Regina Maria Bringel Martins Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil Memórias do Instituto Oswaldo Cruz. Hepatitis E virus HEV epidemiology non-A, non-B, non-C hepatitis |
author_facet |
Nara Rubia de Freitas Edna Braz Rocha de Santana Ágabo Macedo da Costa e Silva Sueli Meira da Silva Sheila Araújo Teles Noemi Rovaris Gardinali Marcelo Alves Pinto Regina Maria Bringel Martins |
author_sort |
Nara Rubia de Freitas |
title |
Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil |
title_short |
Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil |
title_full |
Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil |
title_fullStr |
Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil |
title_full_unstemmed |
Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil |
title_sort |
hepatitis e virus infection in patients with acute non-a, non-b, non-c hepatitis in central brazil |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
1678-8060 |
description |
Hepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From April 2012 to October 2014, a cross-sectional study was conducted among 379 patients with acute non-A, non-B, non-C hepatitis in the City of Goiania, Central Brazil. Serum samples of all patients were tested for serological markers of HEV infection (anti-HEV IgM and IgG) by ELISA. Positive samples were confirmed using immunoblot test. Anti-HEV IgM and IgG positive samples were tested for HEV RNA. Of the 379 serum samples, one (0.3%) and 20 (5.3%) were positive for anti-HEV IgM and IgG, respectively. HEV RNA was not found in any sample positive for IgM and/or IgG anti-HEV. After multivariate analysis, low education level was independently associated with HEV seropositivity (p = 0.005), as well as living in rural area, with a borderline p-value (p = 0.056). In conclusion, HEV may be responsible for sporadic self-limited cases of acute hepatitis in Central Brazil. |
topic |
Hepatitis E virus HEV epidemiology non-A, non-B, non-C hepatitis |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016005020103&lng=en&tlng=en |
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