Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity
Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 e...
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2011-01-01
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doaj-45064b4135074d8e9acfdd9c33160f372020-11-25T01:20:24ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852011-01-01344587591Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversityNuzhat N. KabirJulhash U. KaziReversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400010ePKkinomeaPKbovine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nuzhat N. Kabir Julhash U. Kazi |
spellingShingle |
Nuzhat N. Kabir Julhash U. Kazi Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity Genetics and Molecular Biology ePK kinome aPK bovine |
author_facet |
Nuzhat N. Kabir Julhash U. Kazi |
author_sort |
Nuzhat N. Kabir |
title |
Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity |
title_short |
Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity |
title_full |
Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity |
title_fullStr |
Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity |
title_full_unstemmed |
Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity |
title_sort |
comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1415-4757 1678-4685 |
publishDate |
2011-01-01 |
description |
Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties. |
topic |
ePK kinome aPK bovine |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400010 |
work_keys_str_mv |
AT nuzhatnkabir comparativeanalysisofhumanandbovineproteinkinasesrevealsuniquerelationshipandfunctionaldiversity AT julhashukazi comparativeanalysisofhumanandbovineproteinkinasesrevealsuniquerelationshipandfunctionaldiversity |
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1725134491882618880 |