Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms

Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms

(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D s...

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Main Authors: Manuel Föcker, Nina Timmesfeld, Judith Bühlmeier, Denise Zwanziger, Dagmar Führer, Corinna Grasemann, Stefan Ehrlich, Karin Egberts, Christian Fleischhaker, Christoph Wewetzer, Ida Wessing, Jochen Seitz, Beate Herpertz-Dahlmann, Johannes Hebebrand, Lars Libuda
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Nutrients
Subjects:
vitamin D
supplements
anorexia nervosa
depressive symptoms
adolescents
Online Access:https://www.mdpi.com/2072-6643/13/7/2356
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spelling doaj-450f805e81954ff3b0316e51d9507a952021-07-23T13:58:50ZengMDPI AGNutrients2072-66432021-07-01132356235610.3390/nu13072356Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive SymptomsManuel Föcker0Nina Timmesfeld1Judith Bühlmeier2Denise Zwanziger3Dagmar Führer4Corinna Grasemann5Stefan Ehrlich6Karin Egberts7Christian Fleischhaker8Christoph Wewetzer9Ida Wessing10Jochen Seitz11Beate Herpertz-Dahlmann12Johannes Hebebrand13Lars Libuda14Department of Child and Adolescent Psychiatry, University Hospital Münster, 48149 Münster, GermanyDepartment of Medical Informatics, Biometry and Epidemiology, Ruhr-University Bochum, 44780 Bochum, GermanyDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Endocrinology, Diabetes and Metabolism, Division of Laboratory Research, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Endocrinology, Diabetes and Metabolism, Division of Laboratory Research, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Pediatrics, Division of Rare Diseases, St Josef-Hospital, and CeSER, Ruhr-University Bochum, 44791 Bochum, GermanyDepartment of Child and Adolescent Psychiatry & Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, 01307 Dresden, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, 97080 Wuerzburg, GermanyDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Freiburg, 79104 Freiburg, GermanyDepartment of Child and Adolescent Psychiatry and Psychotherapy, Kliniken der Stadt Köln, 51067 Cologne, GermanyDepartment of Child and Adolescent Psychiatry, University Hospital Münster, 48149 Münster, GermanyClinic for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, 52074 Aachen, GermanyClinic for Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital RWTH Aachen, 52074 Aachen, GermanyDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany(1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.https://www.mdpi.com/2072-6643/13/7/2356vitamin Dsupplementsanorexia nervosadepressive symptomsadolescents
collection DOAJ
language English
format Article
sources DOAJ
author Manuel Föcker
Nina Timmesfeld
Judith Bühlmeier
Denise Zwanziger
Dagmar Führer
Corinna Grasemann
Stefan Ehrlich
Karin Egberts
Christian Fleischhaker
Christoph Wewetzer
Ida Wessing
Jochen Seitz
Beate Herpertz-Dahlmann
Johannes Hebebrand
Lars Libuda
spellingShingle Manuel Föcker
Nina Timmesfeld
Judith Bühlmeier
Denise Zwanziger
Dagmar Führer
Corinna Grasemann
Stefan Ehrlich
Karin Egberts
Christian Fleischhaker
Christoph Wewetzer
Ida Wessing
Jochen Seitz
Beate Herpertz-Dahlmann
Johannes Hebebrand
Lars Libuda
Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
Nutrients
vitamin D
supplements
anorexia nervosa
depressive symptoms
adolescents
author_facet Manuel Föcker
Nina Timmesfeld
Judith Bühlmeier
Denise Zwanziger
Dagmar Führer
Corinna Grasemann
Stefan Ehrlich
Karin Egberts
Christian Fleischhaker
Christoph Wewetzer
Ida Wessing
Jochen Seitz
Beate Herpertz-Dahlmann
Johannes Hebebrand
Lars Libuda
author_sort Manuel Föcker
title Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
title_short Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
title_full Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
title_fullStr Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
title_full_unstemmed Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
title_sort vitamin d level trajectories of adolescent patients with anorexia nervosa at inpatient admission, during treatment, and at one year follow up: association with depressive symptoms
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2021-07-01
description (1) Background: Evidence has accumulated that patients with anorexia nervosa (AN) are at higher risk for vitamin D deficiency than healthy controls. In epidemiologic studies, low 25(OH) vitamin D (25(OH)D) levels were associated with depression. This study analyzed the relationship between 25(OH)D serum levels in adolescent patients and AN and depressive symptoms over the course of treatment. (2) Methods: 25(OH)D levels and depressive symptoms were analyzed in 93 adolescent (in-)patients with AN from the Anorexia Nervosa Day patient versus Inpatient (ANDI) multicenter trial at clinic admission, discharge, and 1 year follow up. Mixed regression models were used to analyze the relationship between 25(OH)D levels and depressive symptoms assessed by the Beck Depression Inventory (BDI-II). (3) Results: Although mean 25(OH)D levels constantly remained in recommended ranges (≥50 nmol/L) during AN treatment, levels decreased from (in)patient admission to 1 year follow up. Levels of 25(OH)D were neither cross-sectionally, prospectively, nor longitudinally associated with the BDI-II score. (4) Conclusions: This study did not confirm that 25(OH)D levels are associated with depressive symptoms in patients with AN. However, increasing risks of vitamin D deficiency over the course of AN treatment indicate that clinicians should monitor 25(OH)D levels.
topic vitamin D
supplements
anorexia nervosa
depressive symptoms
adolescents
url https://www.mdpi.com/2072-6643/13/7/2356
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