Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Cooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call autophagy-related endomembranes.
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2016-06-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms11942 |
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doaj-452ea8b8d9b2466d9eb39259519916df2021-05-11T11:05:48ZengNature Publishing GroupNature Communications2041-17232016-06-017111810.1038/ncomms11942Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranesRachel Barrow-McGee0Naoki Kishi1Carine Joffre2Ludovic Ménard3Alexia Hervieu4Bakhouche A. Bakhouche5Alejandro J. Noval6Anja Mai7Camilo Guzmán8Luisa Robbez-Masson9Xavier Iturrioz10James Hulit11Caroline H. Brennan12Ian R. Hart13Peter J. Parker14Johanna Ivaska15Stéphanie Kermorgant16Spatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareUniversity of Turku, Centre for Biotechnology and VTT Technical Research Centre of FinlandUniversity of Turku, Centre for Biotechnology and VTT Technical Research Centre of FinlandSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareProtein Phosphorylation Laboratory, Francis Crick InstituteSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareSchool of Biological and Chemical Sciences, Queen Mary University of LondonCentre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareProtein Phosphorylation Laboratory, Francis Crick InstituteUniversity of Turku, Centre for Biotechnology and VTT Technical Research Centre of FinlandSpatial Signalling Team, Centre for Tumour Biology, Barts Cancer Institute—A Cancer Research UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse SquareCooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call autophagy-related endomembranes.https://doi.org/10.1038/ncomms11942 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rachel Barrow-McGee Naoki Kishi Carine Joffre Ludovic Ménard Alexia Hervieu Bakhouche A. Bakhouche Alejandro J. Noval Anja Mai Camilo Guzmán Luisa Robbez-Masson Xavier Iturrioz James Hulit Caroline H. Brennan Ian R. Hart Peter J. Parker Johanna Ivaska Stéphanie Kermorgant |
spellingShingle |
Rachel Barrow-McGee Naoki Kishi Carine Joffre Ludovic Ménard Alexia Hervieu Bakhouche A. Bakhouche Alejandro J. Noval Anja Mai Camilo Guzmán Luisa Robbez-Masson Xavier Iturrioz James Hulit Caroline H. Brennan Ian R. Hart Peter J. Parker Johanna Ivaska Stéphanie Kermorgant Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes Nature Communications |
author_facet |
Rachel Barrow-McGee Naoki Kishi Carine Joffre Ludovic Ménard Alexia Hervieu Bakhouche A. Bakhouche Alejandro J. Noval Anja Mai Camilo Guzmán Luisa Robbez-Masson Xavier Iturrioz James Hulit Caroline H. Brennan Ian R. Hart Peter J. Parker Johanna Ivaska Stéphanie Kermorgant |
author_sort |
Rachel Barrow-McGee |
title |
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes |
title_short |
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes |
title_full |
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes |
title_fullStr |
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes |
title_full_unstemmed |
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes |
title_sort |
beta 1-integrin–c-met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-06-01 |
description |
Cooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call autophagy-related endomembranes. |
url |
https://doi.org/10.1038/ncomms11942 |
work_keys_str_mv |
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