Formaldehyde and De/Methylation in Age-Related Cognitive Impairment
Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-comp...
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doaj-4534cb3e040a4a1f996ec220d691e8f32021-07-01T00:06:18ZengMDPI AGGenes2073-44252021-06-011291391310.3390/genes12060913Formaldehyde and De/Methylation in Age-Related Cognitive ImpairmentTing Li0Yan Wei1Meihua Qu2Lixian Mou3Junye Miao4Mengqi Xi5Ying Liu6Rongqiao He7Bayannur Hospital, Bayannur 015000, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, ChinaTranslational Medical Center, Weifang Second People’s Hospital, The Second Affiliated Hospital of Weifang Medical University, Weifang 261041, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, ChinaFormaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets.https://www.mdpi.com/2073-4425/12/6/913formaldehydeepigeneticsage-related cognitive impairmentmethylationdemethylationgenotoxin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting Li Yan Wei Meihua Qu Lixian Mou Junye Miao Mengqi Xi Ying Liu Rongqiao He |
spellingShingle |
Ting Li Yan Wei Meihua Qu Lixian Mou Junye Miao Mengqi Xi Ying Liu Rongqiao He Formaldehyde and De/Methylation in Age-Related Cognitive Impairment Genes formaldehyde epigenetics age-related cognitive impairment methylation demethylation genotoxin |
author_facet |
Ting Li Yan Wei Meihua Qu Lixian Mou Junye Miao Mengqi Xi Ying Liu Rongqiao He |
author_sort |
Ting Li |
title |
Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_short |
Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_full |
Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_fullStr |
Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_full_unstemmed |
Formaldehyde and De/Methylation in Age-Related Cognitive Impairment |
title_sort |
formaldehyde and de/methylation in age-related cognitive impairment |
publisher |
MDPI AG |
series |
Genes |
issn |
2073-4425 |
publishDate |
2021-06-01 |
description |
Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets. |
topic |
formaldehyde epigenetics age-related cognitive impairment methylation demethylation genotoxin |
url |
https://www.mdpi.com/2073-4425/12/6/913 |
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