Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors

Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors

Summary: Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a polarized, laminated architecture. In static cultures, organoid development may be hindered by limitations in diffusion of oxygen and nutrients. Herein, we report a bioproces...

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Bibliographic Details
Main Authors: Tyler DiStefano, Holly Yu Chen, Christopher Panebianco, Koray Dogan Kaya, Matthew J. Brooks, Linn Gieser, Nicole Y. Morgan, Tom Pohida, Anand Swaroop
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Stem Cell Reports
Subjects:
iPSC
embryonic stem cell
in vitro organogenesis
retina development
3-D organoid culture
retinal disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117304873

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