Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma
The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a...
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doaj-453f312f089f4a379554509a476dcdd12020-11-25T00:49:06ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-04-011546703671610.3390/ijms15046703ijms15046703Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin LymphomaHee Nam Kim0Nan Young Kim1Li Yu2Yeo-Kyeoung Kim3Il-Kwon Lee4Deok-Hwan Yang5Je-Jung Lee6Min-Ho Shin7Kyeong-Soo Park8Jin-Su Choi9Hyeoung-Joon Kim10Center for Creative Biomedical Scientists, Chonnam National University, Gwangju 501-746, KoreaEnvironmental Health Center for Childhood Leukemia and Cancer, Chonnam National University Hwasun Hospital, Jeollanamdo 519-763, KoreaEnvironmental Health Center for Childhood Leukemia and Cancer, Chonnam National University Hwasun Hospital, Jeollanamdo 519-763, KoreaDepartment of Hematology/Oncology, Chonnam National University Hwasun Hospital 160 Ilsim-ri, Hwasun-eup, Hwasun-gun, Jellanam-do 519-809, KoreaEnvironmental Health Center for Childhood Leukemia and Cancer, Chonnam National University Hwasun Hospital, Jeollanamdo 519-763, KoreaDepartment of Hematology/Oncology, Chonnam National University Hwasun Hospital 160 Ilsim-ri, Hwasun-eup, Hwasun-gun, Jellanam-do 519-809, KoreaDepartment of Hematology/Oncology, Chonnam National University Hwasun Hospital 160 Ilsim-ri, Hwasun-eup, Hwasun-gun, Jellanam-do 519-809, KoreaCenter for Creative Biomedical Scientists, Chonnam National University, Gwangju 501-746, KoreaDepartment of Preventive Medicine, College of Medicine, Seonam University, Namwon 590-711, KoreaDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju 501-746, KoreaEnvironmental Health Center for Childhood Leukemia and Cancer, Chonnam National University Hwasun Hospital, Jeollanamdo 519-763, KoreaThe damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a population-based study in Korea (694 cases and 1700 controls). Four genotypes of DNA repair pathway genes (XRCC1 399 GA, OGG1 326 GG, BRCA1 871 TT, and WRN 787 TT) were associated with a decreased risk for NHL [odds ratio (OR)XRCC1 GA = 0.80, p = 0.02; OROGG1 GG = 0.70, p = 0.008; ORBRCA1 TT = 0.71, p = 0.048; ORWRN TT = 0.68, p = 0.01]. Conversely, the MGMT 115 CT genotype was associated with an increased risk for NHL (OR = 1.25, p = 0.04). In the MDR1 gene, the 1236 CC genotype was associated with a decreased risk for NHL (OR = 0.74, p = 0.04), and the 3435 CT and TT genotypes were associated with an increased risk (OR3435CT = 1.50, p < 0.0001; OR3435TT = 1.43, p = 0.02). These results suggest that polymorphisms in the DNA repair genes XRCC1, OGG1, BRCA1, WRN1, and MGMT and in the MDR1 gene may affect the risk for NHL in Korean patients.http://www.mdpi.com/1422-0067/15/4/6703NHLpolymorphismassociationDNA repairMDR1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hee Nam Kim Nan Young Kim Li Yu Yeo-Kyeoung Kim Il-Kwon Lee Deok-Hwan Yang Je-Jung Lee Min-Ho Shin Kyeong-Soo Park Jin-Su Choi Hyeoung-Joon Kim |
spellingShingle |
Hee Nam Kim Nan Young Kim Li Yu Yeo-Kyeoung Kim Il-Kwon Lee Deok-Hwan Yang Je-Jung Lee Min-Ho Shin Kyeong-Soo Park Jin-Su Choi Hyeoung-Joon Kim Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma International Journal of Molecular Sciences NHL polymorphism association DNA repair MDR1 |
author_facet |
Hee Nam Kim Nan Young Kim Li Yu Yeo-Kyeoung Kim Il-Kwon Lee Deok-Hwan Yang Je-Jung Lee Min-Ho Shin Kyeong-Soo Park Jin-Su Choi Hyeoung-Joon Kim |
author_sort |
Hee Nam Kim |
title |
Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_short |
Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_full |
Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_fullStr |
Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_full_unstemmed |
Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_sort |
polymorphisms in dna repair genes and mdr1 and the risk for non-hodgkin lymphoma |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2014-04-01 |
description |
The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a population-based study in Korea (694 cases and 1700 controls). Four genotypes of DNA repair pathway genes (XRCC1 399 GA, OGG1 326 GG, BRCA1 871 TT, and WRN 787 TT) were associated with a decreased risk for NHL [odds ratio (OR)XRCC1 GA = 0.80, p = 0.02; OROGG1 GG = 0.70, p = 0.008; ORBRCA1 TT = 0.71, p = 0.048; ORWRN TT = 0.68, p = 0.01]. Conversely, the MGMT 115 CT genotype was associated with an increased risk for NHL (OR = 1.25, p = 0.04). In the MDR1 gene, the 1236 CC genotype was associated with a decreased risk for NHL (OR = 0.74, p = 0.04), and the 3435 CT and TT genotypes were associated with an increased risk (OR3435CT = 1.50, p < 0.0001; OR3435TT = 1.43, p = 0.02). These results suggest that polymorphisms in the DNA repair genes XRCC1, OGG1, BRCA1, WRN1, and MGMT and in the MDR1 gene may affect the risk for NHL in Korean patients. |
topic |
NHL polymorphism association DNA repair MDR1 |
url |
http://www.mdpi.com/1422-0067/15/4/6703 |
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