Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma
Objective: To study the effect of serum HE4 and CP2 contents on the expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma. Methods: A total of 40 cases of patients who were diagnosed with endometrial carcinoma in our hospi...
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doaj-454992c8984248a1b24f38b7f2fc52e92020-11-24T22:49:20ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372016-07-0122138588Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinomaZhe Zhou0Xin Jiang1Ji-Cheng Song2Hong-Yan Jia3Gynecology Department, Lianyungang Maternal and Child Health Hospital of Jiangsu Province, Lianyungang City, Jiangsu Province, 222000, ChinaPathology Department, Lianyungang Maternal and Child Health Hospital of Jiangsu Province, Lianyungang City, Jiangsu Province, 222000, ChiLaboratory Medicine Department, Lianyungang Maternal and Child Health Hospital of Jiangsu Province, Lianyungang City, Jiangsu Province, 222000, ChinaGynecology Department, Lianyungang Maternal and Child Health Hospital of Jiangsu Province, Lianyungang City, Jiangsu Province, 222000, ChinaObjective: To study the effect of serum HE4 and CP2 contents on the expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma. Methods: A total of 40 cases of patients who were diagnosed with endometrial carcinoma in our hospital from May 2013 to March 2016 as well as 40 cases of healthy volunteers who received physical examination in our hospital during the same period were selected for study, serum samples were collected to detect HE4, c-myc, ZEB1, CP2, sTn, CA125, CA199 contents, and endometrial carcinoma tissue as well as para-carcinoma tissue were collected to detect P53, E-cad, EpCAM, C-erbB-2, Ki-67 and MACC1 contents. Results: Serum CP2 and HE4 contents of patients with endometrial carcinoma were significantly higher than those of healthy volunteers, and serum CP2 and HE4 contents of endometrial carcinoma patients with FIGO III-IV stage, low differentiation, muscular layer involvement more than 1/2 and cervical involvement were significantly higher than those of endometrial carcinoma patients with FIGO I-II stage, middle and high differentiation, muscular layer involvement less than 1/2 and without cervical involvement; serum CA125, CA199, c-myc, sTn and ZEB1 contents of patients with endometrial carcinoma were significantly higher than those of healthy volunteers and positively correlated with serum HE4 and CP2; P53 and E-cad contents in endometrial carcinoma tissue were significantly lower than those in para-carcinoma tissue and negatively correlated with serum HE4 and CP2, and EpCAM, C-erbB-2, Ki-67 and MACC1 contents were significantly higher than those in para-carcinoma tissue and positively correlated with serum HE4 and CP2. Conclusions: Serum HE4 and CP2 contents abnormally increase in patients with endometrial carcinoma, and serum HE4 and CP2 can be used to assess the clinical pathology of tumor as well as the degree of tumor tissue proliferation.http://www.hnykdxxb.com/PDF/201613/23.pdfEndometrial carcinomaHE4CP2Proto-oncogene |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhe Zhou Xin Jiang Ji-Cheng Song Hong-Yan Jia |
spellingShingle |
Zhe Zhou Xin Jiang Ji-Cheng Song Hong-Yan Jia Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma Journal of Hainan Medical University Endometrial carcinoma HE4 CP2 Proto-oncogene |
author_facet |
Zhe Zhou Xin Jiang Ji-Cheng Song Hong-Yan Jia |
author_sort |
Zhe Zhou |
title |
Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma |
title_short |
Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma |
title_full |
Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma |
title_fullStr |
Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma |
title_full_unstemmed |
Effect of serum HE4 and CP2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma |
title_sort |
effect of serum he4 and cp2 contents on expression of clinical pathological molecules and proliferation molecules in tumor tissue of patients with endometrial carcinoma |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2016-07-01 |
description |
Objective: To study the effect of serum HE4 and CP2 contents on the expression of clinical
pathological molecules and proliferation molecules in tumor tissue of patients with endometrial
carcinoma. Methods: A total of 40 cases of patients who were diagnosed with endometrial
carcinoma in our hospital from May 2013 to March 2016 as well as 40 cases of healthy
volunteers who received physical examination in our hospital during the same period were
selected for study, serum samples were collected to detect HE4, c-myc, ZEB1, CP2, sTn,
CA125, CA199 contents, and endometrial carcinoma tissue as well as para-carcinoma tissue
were collected to detect P53, E-cad, EpCAM, C-erbB-2, Ki-67 and MACC1 contents. Results:
Serum CP2 and HE4 contents of patients with endometrial carcinoma were significantly higher
than those of healthy volunteers, and serum CP2 and HE4 contents of endometrial carcinoma
patients with FIGO III-IV stage, low differentiation, muscular layer involvement more than
1/2 and cervical involvement were significantly higher than those of endometrial carcinoma
patients with FIGO I-II stage, middle and high differentiation, muscular layer involvement
less than 1/2 and without cervical involvement; serum CA125, CA199, c-myc, sTn and ZEB1
contents of patients with endometrial carcinoma were significantly higher than those of healthy
volunteers and positively correlated with serum HE4 and CP2; P53 and E-cad contents in
endometrial carcinoma tissue were significantly lower than those in para-carcinoma tissue and
negatively correlated with serum HE4 and CP2, and EpCAM, C-erbB-2, Ki-67 and MACC1
contents were significantly higher than those in para-carcinoma tissue and positively correlated
with serum HE4 and CP2. Conclusions: Serum HE4 and CP2 contents abnormally increase
in patients with endometrial carcinoma, and serum HE4 and CP2 can be used to assess the
clinical pathology of tumor as well as the degree of tumor tissue proliferation. |
topic |
Endometrial carcinoma HE4 CP2 Proto-oncogene |
url |
http://www.hnykdxxb.com/PDF/201613/23.pdf |
work_keys_str_mv |
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