AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression

AMPK activation induced in pemetrexed‐treated cells is associated with development of drug resistance independently of target enzyme expression

Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first‐line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and pyrimidine synthesis, and elevated activity of these enzymes in tumors is often linked with resistance to PEM. The a...

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Bibliographic Details
Main Authors: Yiyang Qin, Ikuo Sekine, Michiko Hanazono, Takao Morinaga, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Naoto Yamaguchi, Masatoshi Tagawa
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Molecular Oncology
Subjects:
AMP‐activated protein kinase
drug resistance
mesothelioma
mTORC1
pemetrexed
Online Access:https://doi.org/10.1002/1878-0261.12496

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