Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise
Parkinson’s disease (PD) is a common neurodegenerative disorder classically characterized by symptoms of motor impairment (e.g., tremor and rigidity), but also presenting with important non-motor impairments. There is evidence for the reduced activity of both the parasympathetic and sympathetic limb...
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2021-03-01
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doaj-455c832aaa6b4607937eea434aec3e2a2021-03-19T05:14:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-03-011210.3389/fphys.2021.626640626640Autonomic Function in Patients With Parkinson’s Disease: From Rest to ExerciseJeann L. Sabino-Carvalho0James P. Fisher1Lauro C. Vianna2Lauro C. Vianna3NeuroV̇ASQ̇ – Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasília, Brasília, BrazilManaaki Mānawa – The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New ZealandNeuroV̇ASQ̇ – Integrative Physiology Laboratory, Faculty of Physical Education, University of Brasília, Brasília, BrazilGraduate Program in Medical Sciences, Faculty of Medicine, University of Brasília, Brasília, BrazilParkinson’s disease (PD) is a common neurodegenerative disorder classically characterized by symptoms of motor impairment (e.g., tremor and rigidity), but also presenting with important non-motor impairments. There is evidence for the reduced activity of both the parasympathetic and sympathetic limbs of the autonomic nervous system at rest in PD. Moreover, inappropriate autonomic adjustments accompany exercise, which can lead to inadequate hemodynamic responses, the failure to match the metabolic demands of working skeletal muscle and exercise intolerance. The underlying mechanisms remain unclear, but relevant alterations in several discrete central regions (e.g., dorsal motor nucleus of the vagus nerve, intermediolateral cell column) have been identified. Herein, we critically evaluate the clinically significant and complex associations between the autonomic dysfunction, fatigue and exercise capacity in PD.https://www.frontiersin.org/articles/10.3389/fphys.2021.626640/fullexercisedorsal motor nucleus of the vagus nerveparasympathetic activitysympathetic activityblood pressure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeann L. Sabino-Carvalho James P. Fisher Lauro C. Vianna Lauro C. Vianna |
spellingShingle |
Jeann L. Sabino-Carvalho James P. Fisher Lauro C. Vianna Lauro C. Vianna Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise Frontiers in Physiology exercise dorsal motor nucleus of the vagus nerve parasympathetic activity sympathetic activity blood pressure |
author_facet |
Jeann L. Sabino-Carvalho James P. Fisher Lauro C. Vianna Lauro C. Vianna |
author_sort |
Jeann L. Sabino-Carvalho |
title |
Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise |
title_short |
Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise |
title_full |
Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise |
title_fullStr |
Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise |
title_full_unstemmed |
Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise |
title_sort |
autonomic function in patients with parkinson’s disease: from rest to exercise |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-03-01 |
description |
Parkinson’s disease (PD) is a common neurodegenerative disorder classically characterized by symptoms of motor impairment (e.g., tremor and rigidity), but also presenting with important non-motor impairments. There is evidence for the reduced activity of both the parasympathetic and sympathetic limbs of the autonomic nervous system at rest in PD. Moreover, inappropriate autonomic adjustments accompany exercise, which can lead to inadequate hemodynamic responses, the failure to match the metabolic demands of working skeletal muscle and exercise intolerance. The underlying mechanisms remain unclear, but relevant alterations in several discrete central regions (e.g., dorsal motor nucleus of the vagus nerve, intermediolateral cell column) have been identified. Herein, we critically evaluate the clinically significant and complex associations between the autonomic dysfunction, fatigue and exercise capacity in PD. |
topic |
exercise dorsal motor nucleus of the vagus nerve parasympathetic activity sympathetic activity blood pressure |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.626640/full |
work_keys_str_mv |
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