Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeut...
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MDPI AG
2020-02-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/3/36 |
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doaj-456951c03e1b4c2c88ff9e29c81b1c342020-11-25T03:47:52ZengMDPI AGPharmaceuticals1424-82472020-02-011333610.3390/ph13030036ph13030036Bioisosteric Replacement as a Tool in Anti-HIV Drug DesignAlexej Dick0Simon Cocklin1Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Rooms 10307, 10309, and 10315, 245 North 15th Street, Philadelphia, PA 19102, USADepartment of Biochemistry & Molecular Biology, Drexel University College of Medicine, Rooms 10307, 10309, and 10315, 245 North 15th Street, Philadelphia, PA 19102, USABioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeutics. Moreover, we cover field-based, computational methodologies for bioisosteric replacement, using studies from our group as an example. It is our hope that this review will serve to highlight the utility and potential of bioisosteric replacement in the continuing search for new and improved anti-HIV drugs.https://www.mdpi.com/1424-8247/13/3/36bioisostereshiv-1antiviralcomputer-aided drug designenvelopereverse transcriptaseproteaseintegrasetatvif |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alexej Dick Simon Cocklin |
| spellingShingle |
Alexej Dick Simon Cocklin Bioisosteric Replacement as a Tool in Anti-HIV Drug Design Pharmaceuticals bioisosteres hiv-1 antiviral computer-aided drug design envelope reverse transcriptase protease integrase tat vif |
| author_facet |
Alexej Dick Simon Cocklin |
| author_sort |
Alexej Dick |
| title |
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design |
| title_short |
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design |
| title_full |
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design |
| title_fullStr |
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design |
| title_full_unstemmed |
Bioisosteric Replacement as a Tool in Anti-HIV Drug Design |
| title_sort |
bioisosteric replacement as a tool in anti-hiv drug design |
| publisher |
MDPI AG |
| series |
Pharmaceuticals |
| issn |
1424-8247 |
| publishDate |
2020-02-01 |
| description |
Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeutics. Moreover, we cover field-based, computational methodologies for bioisosteric replacement, using studies from our group as an example. It is our hope that this review will serve to highlight the utility and potential of bioisosteric replacement in the continuing search for new and improved anti-HIV drugs. |
| topic |
bioisosteres hiv-1 antiviral computer-aided drug design envelope reverse transcriptase protease integrase tat vif |
| url |
https://www.mdpi.com/1424-8247/13/3/36 |
| work_keys_str_mv |
AT alexejdick bioisostericreplacementasatoolinantihivdrugdesign AT simoncocklin bioisostericreplacementasatoolinantihivdrugdesign |
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1724501563390558208 |