Bioisosteric Replacement as a Tool in Anti-HIV Drug Design

Bioisosteric replacement is a powerful tool for modulating the drug-like properties, toxicity, and chemical space of experimental therapeutics. In this review, we focus on selected cases where bioisosteric replacement and scaffold hopping have been used in the development of new anti-HIV-1 therapeut...

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Bibliographic Details
Main Authors: Alexej Dick, Simon Cocklin
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceuticals
Subjects:
tat
vif
Online Access:https://www.mdpi.com/1424-8247/13/3/36