Radiolabeled Dendrimers for Nuclear Medicine Applications

Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclid...

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Main Authors:	Lingzhou Zhao, Meilin Zhu, Yujie Li, Yan Xing, Jinhua Zhao
Format:	Article
Language:	English
Published:	MDPI AG 2017-08-01
Series:	Molecules
Subjects:	dendrimers nuclear medicine PET SPECT radionuclide therapy radiolabeling
Online Access:	https://www.mdpi.com/1420-3049/22/9/1350

id	doaj-45776788db7c4c65870d00b10196d7be
record_format	Article
spelling	doaj-45776788db7c4c65870d00b10196d7be2020-11-24T21:24:58ZengMDPI AGMolecules1420-30492017-08-01229135010.3390/molecules22091350molecules22091350Radiolabeled Dendrimers for Nuclear Medicine ApplicationsLingzhou Zhao0Meilin Zhu1Yujie Li2Yan Xing3Jinhua Zhao4Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaBasic Medical College, Ningxia Medical University, Yinchuan 750004, Ningxia, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaRecent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclides, dendrimers provide versatile platforms in this filed to build abundant multifunctional radiolabeled nanoparticles for nuclear medicine applications. This review gives special focus to recent advances in dendrimer-based nuclear medicine agents for the imaging and treatment of cancer, cardiovascular and other diseases. Radiolabeling strategies for different radionuclides and several challenges involved in clinical translation of radiolabeled dendrimers are extensively discussed.https://www.mdpi.com/1420-3049/22/9/1350dendrimersnuclear medicinePETSPECTradionuclide therapyradiolabeling
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lingzhou Zhao Meilin Zhu Yujie Li Yan Xing Jinhua Zhao
spellingShingle	Lingzhou Zhao Meilin Zhu Yujie Li Yan Xing Jinhua Zhao Radiolabeled Dendrimers for Nuclear Medicine Applications Molecules dendrimers nuclear medicine PET SPECT radionuclide therapy radiolabeling
author_facet	Lingzhou Zhao Meilin Zhu Yujie Li Yan Xing Jinhua Zhao
author_sort	Lingzhou Zhao
title	Radiolabeled Dendrimers for Nuclear Medicine Applications
title_short	Radiolabeled Dendrimers for Nuclear Medicine Applications
title_full	Radiolabeled Dendrimers for Nuclear Medicine Applications
title_fullStr	Radiolabeled Dendrimers for Nuclear Medicine Applications
title_full_unstemmed	Radiolabeled Dendrimers for Nuclear Medicine Applications
title_sort	radiolabeled dendrimers for nuclear medicine applications
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2017-08-01
description	Recent advances in nuclear medicine have explored nanoscale carriers for targeted delivery of various radionuclides in specific manners to improve the effect of diagnosis and therapy of diseases. Due to the unique molecular architecture allowing facile attachment of targeting ligands and radionuclides, dendrimers provide versatile platforms in this filed to build abundant multifunctional radiolabeled nanoparticles for nuclear medicine applications. This review gives special focus to recent advances in dendrimer-based nuclear medicine agents for the imaging and treatment of cancer, cardiovascular and other diseases. Radiolabeling strategies for different radionuclides and several challenges involved in clinical translation of radiolabeled dendrimers are extensively discussed.
topic	dendrimers nuclear medicine PET SPECT radionuclide therapy radiolabeling
url	https://www.mdpi.com/1420-3049/22/9/1350
work_keys_str_mv	AT lingzhouzhao radiolabeleddendrimersfornuclearmedicineapplications AT meilinzhu radiolabeleddendrimersfornuclearmedicineapplications AT yujieli radiolabeleddendrimersfornuclearmedicineapplications AT yanxing radiolabeleddendrimersfornuclearmedicineapplications AT jinhuazhao radiolabeleddendrimersfornuclearmedicineapplications
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Radiolabeled Dendrimers for Nuclear Medicine Applications

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