Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence
Abstract Background Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the associations between FGF13 in follicular fluid and oocyte developmenta...
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doaj-458418d697f14f3e9f422a525d11a5122020-11-25T03:37:32ZengBMCJournal of Ovarian Research1757-22152018-09-011111610.1186/s13048-018-0455-3Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competenceYu Liu0Shengxian Li1Tao Tao2Xiaoxue Li3Qinling Zhu4Yu Liao5Jing Ma6Yun Sun7Wei Liu8Department of Endocrinology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityCenter for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai JiaoTong UniversityCenter for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai JiaoTong UniversityDepartment of Endocrinology, South Campus, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityDepartment of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityCenter for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai JiaoTong UniversityDepartment of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong UniversityAbstract Background Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the associations between FGF13 in follicular fluid and oocyte developmental competence in patients with polycystic ovary syndrome (PCOS). Methods A cross-sectional study was conducted on 43 patients with PCOS and 32 non-PCOS patients who underwent in vitro fertilization/intracytoplasmic sperm injection treatments. The highest quartiles of follicular fluid (FF)-FGF13 (≥117.51 pg/mL) and FF-total testosterone (FF-TT) (≥51.90 nmol/L) were defined as “elevated” FF-FGF13 levels and “elevated” FF-TT levels, respectively. Results The levels of FF-FGF13 were skewed, with a median of 82.97 pg/mL (59.79–117.51 pg/mL) in 75 patients. The prevalence of elevated FF-TT levels was significantly higher in the PCOS patients with elevated FF-FGF13 levels than in those without (64.3% vs. 35.7%, adjusted P = 0.0096). FF-TT and increased ovarian volume (> 10 mL for one or both ovaries) were positively correlated with FF-FGF13 in PCOS patients (r = 0.37, P = 0.013; r = 0.33, P = 0.032). A negative association was evident between FF-FGF13 and the MII oocyte rate in the multiple linear regression analysis (β = − 0.10, SE = 0.045, adjusted P = 0.027). However, the associations were not evident in the non-PCOS patients. Conclusions Our study suggests the presence of intrafollicular FGF13 in PCOS patients and implies that FGF13 might be involved in the pathophysiological process of PCOS.http://link.springer.com/article/10.1186/s13048-018-0455-3Fibroblast growth factor 13TestosteroneFollicular fluidPolycystic ovary syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu Liu Shengxian Li Tao Tao Xiaoxue Li Qinling Zhu Yu Liao Jing Ma Yun Sun Wei Liu |
spellingShingle |
Yu Liu Shengxian Li Tao Tao Xiaoxue Li Qinling Zhu Yu Liao Jing Ma Yun Sun Wei Liu Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence Journal of Ovarian Research Fibroblast growth factor 13 Testosterone Follicular fluid Polycystic ovary syndrome |
author_facet |
Yu Liu Shengxian Li Tao Tao Xiaoxue Li Qinling Zhu Yu Liao Jing Ma Yun Sun Wei Liu |
author_sort |
Yu Liu |
title |
Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence |
title_short |
Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence |
title_full |
Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence |
title_fullStr |
Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence |
title_full_unstemmed |
Intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence |
title_sort |
intrafollicular fibroblast growth factor 13 in polycystic ovary syndrome: relationship with androgen levels and oocyte developmental competence |
publisher |
BMC |
series |
Journal of Ovarian Research |
issn |
1757-2215 |
publishDate |
2018-09-01 |
description |
Abstract Background Fibroblast growth factor 13 (FGF13) is one of the most highly expressed FGF family members in adult mouse ovary. However, its precise roles in ovarian function remain largely unknown. We sought to evaluate the associations between FGF13 in follicular fluid and oocyte developmental competence in patients with polycystic ovary syndrome (PCOS). Methods A cross-sectional study was conducted on 43 patients with PCOS and 32 non-PCOS patients who underwent in vitro fertilization/intracytoplasmic sperm injection treatments. The highest quartiles of follicular fluid (FF)-FGF13 (≥117.51 pg/mL) and FF-total testosterone (FF-TT) (≥51.90 nmol/L) were defined as “elevated” FF-FGF13 levels and “elevated” FF-TT levels, respectively. Results The levels of FF-FGF13 were skewed, with a median of 82.97 pg/mL (59.79–117.51 pg/mL) in 75 patients. The prevalence of elevated FF-TT levels was significantly higher in the PCOS patients with elevated FF-FGF13 levels than in those without (64.3% vs. 35.7%, adjusted P = 0.0096). FF-TT and increased ovarian volume (> 10 mL for one or both ovaries) were positively correlated with FF-FGF13 in PCOS patients (r = 0.37, P = 0.013; r = 0.33, P = 0.032). A negative association was evident between FF-FGF13 and the MII oocyte rate in the multiple linear regression analysis (β = − 0.10, SE = 0.045, adjusted P = 0.027). However, the associations were not evident in the non-PCOS patients. Conclusions Our study suggests the presence of intrafollicular FGF13 in PCOS patients and implies that FGF13 might be involved in the pathophysiological process of PCOS. |
topic |
Fibroblast growth factor 13 Testosterone Follicular fluid Polycystic ovary syndrome |
url |
http://link.springer.com/article/10.1186/s13048-018-0455-3 |
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